Cisplatin, the Timeless Molecule
Cisplatin was the first metal-based anticancer drug introduced into clinical use. It is a “small” molecule, but it represented a very “big” discovery. Since it was introduced on the market, it has not been withdrawn, despite being not free of side effects, owing to its peculiarity of being highly ef...
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MDPI AG
2025-07-01
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| Series: | Inorganics |
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| Online Access: | https://www.mdpi.com/2304-6740/13/7/246 |
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| author | Annaluisa Mariconda Jessica Ceramella Alessia Catalano Carmela Saturnino Maria Stefania Sinicropi Pasquale Longo |
| author_facet | Annaluisa Mariconda Jessica Ceramella Alessia Catalano Carmela Saturnino Maria Stefania Sinicropi Pasquale Longo |
| author_sort | Annaluisa Mariconda |
| collection | DOAJ |
| description | Cisplatin was the first metal-based anticancer drug introduced into clinical use. It is a “small” molecule, but it represented a very “big” discovery. Since it was introduced on the market, it has not been withdrawn, despite being not free of side effects, owing to its peculiarity of being highly effective in the treatment of cancer. Anticancer activity of the platinum-based complexes was discovered with this molecule; since then, several other platinum-based drugs have been developed and tested in preclinical studies against cancer cells; however, only a few of them reached clinical trials, and their side effects are not much less than cisplatin. Despite the constraints of drug resistance and side effects, chemotherapy remains a fundamental strategy in cancer treatment. Nowadays, cisplatin remains one of the most-used anticancer agents in treating lung, colon, ovary, testicles, bladder, cervix, and many more cancers, although cisplatin resistance represents a major hurdle in cancer treatment. Will there ever be another drug that can overcome the side effects of cisplatin but at the same time be able to block tumors as does cisplatin? |
| format | Article |
| id | doaj-art-f9eb6386cf8b43a0b84c6ffb5ed1e3fe |
| institution | Matheson Library |
| issn | 2304-6740 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Inorganics |
| spelling | doaj-art-f9eb6386cf8b43a0b84c6ffb5ed1e3fe2025-07-25T13:25:28ZengMDPI AGInorganics2304-67402025-07-0113724610.3390/inorganics13070246Cisplatin, the Timeless MoleculeAnnaluisa Mariconda0Jessica Ceramella1Alessia Catalano2Carmela Saturnino3Maria Stefania Sinicropi4Pasquale Longo5Department of Basic and Applied Sciences, University of Basilicata, Via dell’Ateneo Lucano, 10, 85100 Potenza, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via Pietro Bucci, 87036 Arcavacata di Rende, ItalyDepartment of Pharmacy-Drug Sciences, University of Bari “Aldo Moro”, Via Orabona, 4, 70126 Bari, ItalyDepartment of Health Sciences, University of Basilicata, Via dell’Ateneo Lucano, 10, 85100 Potenza, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via Pietro Bucci, 87036 Arcavacata di Rende, ItalyDepartment of Chemistry and Biology “A. Zambelli”, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, ItalyCisplatin was the first metal-based anticancer drug introduced into clinical use. It is a “small” molecule, but it represented a very “big” discovery. Since it was introduced on the market, it has not been withdrawn, despite being not free of side effects, owing to its peculiarity of being highly effective in the treatment of cancer. Anticancer activity of the platinum-based complexes was discovered with this molecule; since then, several other platinum-based drugs have been developed and tested in preclinical studies against cancer cells; however, only a few of them reached clinical trials, and their side effects are not much less than cisplatin. Despite the constraints of drug resistance and side effects, chemotherapy remains a fundamental strategy in cancer treatment. Nowadays, cisplatin remains one of the most-used anticancer agents in treating lung, colon, ovary, testicles, bladder, cervix, and many more cancers, although cisplatin resistance represents a major hurdle in cancer treatment. Will there ever be another drug that can overcome the side effects of cisplatin but at the same time be able to block tumors as does cisplatin?https://www.mdpi.com/2304-6740/13/7/246cisplatinplatinum complexesprecious metalsanticancer drugs |
| spellingShingle | Annaluisa Mariconda Jessica Ceramella Alessia Catalano Carmela Saturnino Maria Stefania Sinicropi Pasquale Longo Cisplatin, the Timeless Molecule Inorganics cisplatin platinum complexes precious metals anticancer drugs |
| title | Cisplatin, the Timeless Molecule |
| title_full | Cisplatin, the Timeless Molecule |
| title_fullStr | Cisplatin, the Timeless Molecule |
| title_full_unstemmed | Cisplatin, the Timeless Molecule |
| title_short | Cisplatin, the Timeless Molecule |
| title_sort | cisplatin the timeless molecule |
| topic | cisplatin platinum complexes precious metals anticancer drugs |
| url | https://www.mdpi.com/2304-6740/13/7/246 |
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