Specific antitumor activity of anti-CA125 CAR-T lymphocytes against CA125-positive and CA125-negative cells

Specific antitumor activity of anti-CA125 CAR-T lymphocytes against CA125-positive and CA125-negative cells

Aim. To evaluate the antitumor efficacy of our developed drug based on cytotoxic T lymphocytes genetically modified with a chimeric antigen receptor (CAR) specific to the CA125 antigen in relation to both CA125-positive and CA125negative cell cultures.Materials and methods. We performed an in vitro...

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Bibliographic Details
Main Authors: T. M. Kulinich, Ya. Yu. Kiseleva, A. M. Shishkin, E. A. Kudinova, O. B. Knyazeva, R. Ranjit, V. K. Bozhenko, V. A. Solodky
Format: Article
Language:Russian
Published: Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University) 2024-07-01
Series:Сеченовский вестник
Subjects:
high-tech drug
ovarian cancer
epithelial ovarian carcinoma
immunotherapy
chimeric anti gen receptor
t-cell therapy
lymphokine-activated killer cells
Online Access:https://www.sechenovmedj.com/jour/article/view/1103
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https://www.sechenovmedj.com/jour/article/view/1103

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