Intrascleral Tunnel Clamping of Fluocinolone Acetonide Implant: A Novel Scleral Fixation Technique
<b>Purpose:</b> This retrospective observational study evaluates the efficacy and safety of a novel scleral fixation technique of the fluocinolone acetonide (FAc) implant in four consecutive patients with post-surgical macular edema (PSME). <b>Case Presentation:</b> Four pati...
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MDPI AG
2025-06-01
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| Online Access: | https://www.mdpi.com/1424-8247/18/6/849 |
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| author | Lucas Sejournet Laurent Kodjikian Thibaud Mathis Alban Comet Pierre Gascon Frederic Matonti |
| author_facet | Lucas Sejournet Laurent Kodjikian Thibaud Mathis Alban Comet Pierre Gascon Frederic Matonti |
| author_sort | Lucas Sejournet |
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| description | <b>Purpose:</b> This retrospective observational study evaluates the efficacy and safety of a novel scleral fixation technique of the fluocinolone acetonide (FAc) implant in four consecutive patients with post-surgical macular edema (PSME). <b>Case Presentation:</b> Four patients with PSME underwent intrascleral tunnel clamping (ITC) of the FAc implant due to lens defects. A 25-gauge sclerotomy was made 3.5 mm from the limbus and the implant was inserted into it until its end reached the edge of the sclera. Then, an 8-0 absorbable suture was passed through the sclera without penetrating the implant, thereby clamping the sclera around the FAc. All the patients showed improvements in best-corrected visual acuity (from a mean of 20/100 at baseline to 20/40) and central retinal thickness (from a mean of 534 µm at baseline to 318 µm) and with no recurrence of macular edema in most cases, without the need for further treatment. In addition, no anterior migration of the FAc implant or ocular hypertension was observed. This procedure effectively reduced the therapeutic burden for these patients. Although scleral fixation of the FAc implant has been described in small series of patients with successful results, this approach remains off-label. <b>Conclusions:</b> Although off-label, ITC of the FAc implant may offer a promising treatment option for patients who would otherwise remain untreated. |
| format | Article |
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| language | English |
| publishDate | 2025-06-01 |
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| spelling | doaj-art-f9ccae4ebe9043fa8858509c3eb1a19c2025-06-25T14:17:42ZengMDPI AGPharmaceuticals1424-82472025-06-0118684910.3390/ph18060849Intrascleral Tunnel Clamping of Fluocinolone Acetonide Implant: A Novel Scleral Fixation TechniqueLucas Sejournet0Laurent Kodjikian1Thibaud Mathis2Alban Comet3Pierre Gascon4Frederic Matonti5Department of Ophthalmology, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 69004 Lyon, FranceDepartment of Ophthalmology, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 69004 Lyon, FranceDepartment of Ophthalmology, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 69004 Lyon, FranceCentre Monticelli Paradis, 13000 Marseille, FranceCentre Monticelli Paradis, 13000 Marseille, FranceCentre Monticelli Paradis, 13000 Marseille, France<b>Purpose:</b> This retrospective observational study evaluates the efficacy and safety of a novel scleral fixation technique of the fluocinolone acetonide (FAc) implant in four consecutive patients with post-surgical macular edema (PSME). <b>Case Presentation:</b> Four patients with PSME underwent intrascleral tunnel clamping (ITC) of the FAc implant due to lens defects. A 25-gauge sclerotomy was made 3.5 mm from the limbus and the implant was inserted into it until its end reached the edge of the sclera. Then, an 8-0 absorbable suture was passed through the sclera without penetrating the implant, thereby clamping the sclera around the FAc. All the patients showed improvements in best-corrected visual acuity (from a mean of 20/100 at baseline to 20/40) and central retinal thickness (from a mean of 534 µm at baseline to 318 µm) and with no recurrence of macular edema in most cases, without the need for further treatment. In addition, no anterior migration of the FAc implant or ocular hypertension was observed. This procedure effectively reduced the therapeutic burden for these patients. Although scleral fixation of the FAc implant has been described in small series of patients with successful results, this approach remains off-label. <b>Conclusions:</b> Although off-label, ITC of the FAc implant may offer a promising treatment option for patients who would otherwise remain untreated.https://www.mdpi.com/1424-8247/18/6/849fluocinolone acetonide implantscleral fixationmacular edema |
| spellingShingle | Lucas Sejournet Laurent Kodjikian Thibaud Mathis Alban Comet Pierre Gascon Frederic Matonti Intrascleral Tunnel Clamping of Fluocinolone Acetonide Implant: A Novel Scleral Fixation Technique Pharmaceuticals fluocinolone acetonide implant scleral fixation macular edema |
| title | Intrascleral Tunnel Clamping of Fluocinolone Acetonide Implant: A Novel Scleral Fixation Technique |
| title_full | Intrascleral Tunnel Clamping of Fluocinolone Acetonide Implant: A Novel Scleral Fixation Technique |
| title_fullStr | Intrascleral Tunnel Clamping of Fluocinolone Acetonide Implant: A Novel Scleral Fixation Technique |
| title_full_unstemmed | Intrascleral Tunnel Clamping of Fluocinolone Acetonide Implant: A Novel Scleral Fixation Technique |
| title_short | Intrascleral Tunnel Clamping of Fluocinolone Acetonide Implant: A Novel Scleral Fixation Technique |
| title_sort | intrascleral tunnel clamping of fluocinolone acetonide implant a novel scleral fixation technique |
| topic | fluocinolone acetonide implant scleral fixation macular edema |
| url | https://www.mdpi.com/1424-8247/18/6/849 |
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