Nanoencapsulated roselle anthocyanins extract extends lifespan in Western diet-fed male Drosophila via enhanced mitochondrial biogenesis
Long-term consumption of a Western diet (WD) increases the risks of obesity and age-related pathologies. Anthocyanins have shown potential in counteracting metabolic dysregulation associated with WD; however, their low stability and bioaccessibility hinder their ability to deliver optimal biological...
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Elsevier
2025-08-01
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| Series: | Journal of Agriculture and Food Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666154325005095 |
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| author | Qianhua Yuan Wanhan Song Ya Wang Yutong Xie Dazhang Deng Nageena Qayyum Huawen Li Honghui Guo |
| author_facet | Qianhua Yuan Wanhan Song Ya Wang Yutong Xie Dazhang Deng Nageena Qayyum Huawen Li Honghui Guo |
| author_sort | Qianhua Yuan |
| collection | DOAJ |
| description | Long-term consumption of a Western diet (WD) increases the risks of obesity and age-related pathologies. Anthocyanins have shown potential in counteracting metabolic dysregulation associated with WD; however, their low stability and bioaccessibility hinder their ability to deliver optimal biological and pharmacological effects. Encapsulation presents significant advantages for enhancing the bioaccessibility of anthocyanins. This study evaluated nanoencapsulated roselle anthocyanins extract (Nano-RAE) in mitigating WD-induced metabolic disturbances and lifespan reduction in Drosophila melanogaster. Male flies were divided into three groups: control, WD, and WD + RAE (5 mg/mL Nano-RAE). Body weight, triglycerides (TG) levels, lifespan, locomotor function, intestinal integrity, oxidative stress markers, mitochondrial function, and related pathways were assessed. Nano-RAE significantly extended the maximum lifespan of WD-fed flies, from 61.1 to 81.9 days. It reduced TG levels, lipid accumulation, and oxidative stress while enhancing antioxidant enzyme activities. Additionally, Nano-RAE enhanced climbing ability, maintained intestinal barrier integrity, and restored mitochondrial function through enhanced mitochondrial biogenesis. These findings supported that Nano-RAE alleviates WD-induced metabolic dysfunction and aging by enhancing mitochondrial biogenesis, highlighting its potential as a dietary intervention for obesity and age-related disorders. |
| format | Article |
| id | doaj-art-f9a1e80da99f49b0a40fcd7a1fe3bf81 |
| institution | Matheson Library |
| issn | 2666-1543 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Agriculture and Food Research |
| spelling | doaj-art-f9a1e80da99f49b0a40fcd7a1fe3bf812025-07-26T05:24:24ZengElsevierJournal of Agriculture and Food Research2666-15432025-08-0122102138Nanoencapsulated roselle anthocyanins extract extends lifespan in Western diet-fed male Drosophila via enhanced mitochondrial biogenesisQianhua Yuan0Wanhan Song1Ya Wang2Yutong Xie3Dazhang Deng4Nageena Qayyum5Huawen Li6Honghui Guo7Department of Nutrition, School of Public Health, Guangdong Medical University, Dongguan 523808, ChinaDepartment of Nutrition, School of Public Health, Guangdong Medical University, Dongguan 523808, ChinaDepartment of Nutrition, School of Public Health, Guangdong Medical University, Dongguan 523808, ChinaDepartment of Nutrition, School of Public Health, Guangdong Medical University, Dongguan 523808, ChinaDepartment of Nutrition, School of Public Health, Guangdong Medical University, Dongguan 523808, ChinaDepartment of Nutrition, School of Public Health, Guangdong Medical University, Dongguan 523808, ChinaDepartment of Nutrition, School of Public Health, Guangdong Medical University, Dongguan 523808, China; Dongguan Key Laboratory for Development and Application of Experimental Animal Resources in Biomedical Industry, Guangdong Medical University, Dongguan 523808, China; Corresponding author. Department of Nutrition, School of Public Health, Guangdong Medical University, Dongguan 523808, China.Department of Nutrition, School of Public Health, Guangdong Medical University, Dongguan 523808, China; Dongguan Key Laboratory for Development and Application of Experimental Animal Resources in Biomedical Industry, Guangdong Medical University, Dongguan 523808, China; Corresponding author. Department of Nutrition, School of Public Health, Guangdong Medical University, Dongguan 523808, China.Long-term consumption of a Western diet (WD) increases the risks of obesity and age-related pathologies. Anthocyanins have shown potential in counteracting metabolic dysregulation associated with WD; however, their low stability and bioaccessibility hinder their ability to deliver optimal biological and pharmacological effects. Encapsulation presents significant advantages for enhancing the bioaccessibility of anthocyanins. This study evaluated nanoencapsulated roselle anthocyanins extract (Nano-RAE) in mitigating WD-induced metabolic disturbances and lifespan reduction in Drosophila melanogaster. Male flies were divided into three groups: control, WD, and WD + RAE (5 mg/mL Nano-RAE). Body weight, triglycerides (TG) levels, lifespan, locomotor function, intestinal integrity, oxidative stress markers, mitochondrial function, and related pathways were assessed. Nano-RAE significantly extended the maximum lifespan of WD-fed flies, from 61.1 to 81.9 days. It reduced TG levels, lipid accumulation, and oxidative stress while enhancing antioxidant enzyme activities. Additionally, Nano-RAE enhanced climbing ability, maintained intestinal barrier integrity, and restored mitochondrial function through enhanced mitochondrial biogenesis. These findings supported that Nano-RAE alleviates WD-induced metabolic dysfunction and aging by enhancing mitochondrial biogenesis, highlighting its potential as a dietary intervention for obesity and age-related disorders.http://www.sciencedirect.com/science/article/pii/S2666154325005095AgingFlavonoidFruit flyMitochondrial dysfunctionNanocapsuleObesity |
| spellingShingle | Qianhua Yuan Wanhan Song Ya Wang Yutong Xie Dazhang Deng Nageena Qayyum Huawen Li Honghui Guo Nanoencapsulated roselle anthocyanins extract extends lifespan in Western diet-fed male Drosophila via enhanced mitochondrial biogenesis Journal of Agriculture and Food Research Aging Flavonoid Fruit fly Mitochondrial dysfunction Nanocapsule Obesity |
| title | Nanoencapsulated roselle anthocyanins extract extends lifespan in Western diet-fed male Drosophila via enhanced mitochondrial biogenesis |
| title_full | Nanoencapsulated roselle anthocyanins extract extends lifespan in Western diet-fed male Drosophila via enhanced mitochondrial biogenesis |
| title_fullStr | Nanoencapsulated roselle anthocyanins extract extends lifespan in Western diet-fed male Drosophila via enhanced mitochondrial biogenesis |
| title_full_unstemmed | Nanoencapsulated roselle anthocyanins extract extends lifespan in Western diet-fed male Drosophila via enhanced mitochondrial biogenesis |
| title_short | Nanoencapsulated roselle anthocyanins extract extends lifespan in Western diet-fed male Drosophila via enhanced mitochondrial biogenesis |
| title_sort | nanoencapsulated roselle anthocyanins extract extends lifespan in western diet fed male drosophila via enhanced mitochondrial biogenesis |
| topic | Aging Flavonoid Fruit fly Mitochondrial dysfunction Nanocapsule Obesity |
| url | http://www.sciencedirect.com/science/article/pii/S2666154325005095 |
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