The impact of Cochrane Reviews that apply network meta-analysis in clinical guidelines: A systematic review.
<h4>Background</h4>Systematic reviews, such as those prepared by Cochrane, are the strongest evidence on which to base recommendations in clinical guidelines. Network meta-analysis (NMA) can be used to combine the results of studies to compare multiple treatments, which is advantageous o...
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| Format: | Article |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0315563 |
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| author | Sarah Donegan James Connor Zarko Alfirevic Catrin Tudur-Smith |
| author_facet | Sarah Donegan James Connor Zarko Alfirevic Catrin Tudur-Smith |
| author_sort | Sarah Donegan |
| collection | DOAJ |
| description | <h4>Background</h4>Systematic reviews, such as those prepared by Cochrane, are the strongest evidence on which to base recommendations in clinical guidelines. Network meta-analysis (NMA) can be used to combine the results of studies to compare multiple treatments, which is advantageous over pair-wise meta-analysis (PW-MA) that compares two treatments. We aimed to summarise which, when, where, who, and why Cochrane Reviews that applied NMA were cited in guidelines; and to compare the citation of NMA reviews in guidelines with PW-MA reviews.<h4>Methods and findings</h4>We carried out a systematic review of Cochrane reviews that applied NMA and we summarised their citation in guidelines. The Cochrane Database of Systematic Reviews was searched (15th January 2024). Additionally, a cohort of Cochrane reviews that applied PW-MA was matched to the NMA reviews. Two authors assessed eligibility and extracted data. We summarised review and guideline characteristics, and the use of the review in guidelines.<h4>Results</h4>Of the 60 included NMA reviews, 26 reviews (43%) were cited in 89 guidelines (1-13 per review). 15 NMA reviews (58%) were first cited within two years of publication, with the remaining 11 reviews (42%) cited 2-6 years later. 52 guideline developers authored the guidelines. The number of citations was higher for NMA than PW-MA reviews (rate ratio 1.53 (1.08 to 2.19), p = 0.02). The number of times reviews were commissioned or cited alongside a recommendation was also higher for NMA than PW-MA reviews (rate ratio 4.40 (1.80 to 13.14), p = 0.003). NMA reviews were more likely to be cited in the text surrounding a recommendation or used for NICE guideline development (1.94 (1.08 to 3.63), p = 0.03).<h4>Conclusions</h4>Cochrane NMA reviews appear to have more impact than PW-MA reviews, but many are not cited in guidelines. Further work is needed to explore the barriers to use of NMAs and promote their use. |
| format | Article |
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| institution | Matheson Library |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-f8bbddaf6ccf45c88f188a7b3a33ead32025-07-25T05:31:16ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-011912e031556310.1371/journal.pone.0315563The impact of Cochrane Reviews that apply network meta-analysis in clinical guidelines: A systematic review.Sarah DoneganJames ConnorZarko AlfirevicCatrin Tudur-Smith<h4>Background</h4>Systematic reviews, such as those prepared by Cochrane, are the strongest evidence on which to base recommendations in clinical guidelines. Network meta-analysis (NMA) can be used to combine the results of studies to compare multiple treatments, which is advantageous over pair-wise meta-analysis (PW-MA) that compares two treatments. We aimed to summarise which, when, where, who, and why Cochrane Reviews that applied NMA were cited in guidelines; and to compare the citation of NMA reviews in guidelines with PW-MA reviews.<h4>Methods and findings</h4>We carried out a systematic review of Cochrane reviews that applied NMA and we summarised their citation in guidelines. The Cochrane Database of Systematic Reviews was searched (15th January 2024). Additionally, a cohort of Cochrane reviews that applied PW-MA was matched to the NMA reviews. Two authors assessed eligibility and extracted data. We summarised review and guideline characteristics, and the use of the review in guidelines.<h4>Results</h4>Of the 60 included NMA reviews, 26 reviews (43%) were cited in 89 guidelines (1-13 per review). 15 NMA reviews (58%) were first cited within two years of publication, with the remaining 11 reviews (42%) cited 2-6 years later. 52 guideline developers authored the guidelines. The number of citations was higher for NMA than PW-MA reviews (rate ratio 1.53 (1.08 to 2.19), p = 0.02). The number of times reviews were commissioned or cited alongside a recommendation was also higher for NMA than PW-MA reviews (rate ratio 4.40 (1.80 to 13.14), p = 0.003). NMA reviews were more likely to be cited in the text surrounding a recommendation or used for NICE guideline development (1.94 (1.08 to 3.63), p = 0.03).<h4>Conclusions</h4>Cochrane NMA reviews appear to have more impact than PW-MA reviews, but many are not cited in guidelines. Further work is needed to explore the barriers to use of NMAs and promote their use.https://doi.org/10.1371/journal.pone.0315563 |
| spellingShingle | Sarah Donegan James Connor Zarko Alfirevic Catrin Tudur-Smith The impact of Cochrane Reviews that apply network meta-analysis in clinical guidelines: A systematic review. PLoS ONE |
| title | The impact of Cochrane Reviews that apply network meta-analysis in clinical guidelines: A systematic review. |
| title_full | The impact of Cochrane Reviews that apply network meta-analysis in clinical guidelines: A systematic review. |
| title_fullStr | The impact of Cochrane Reviews that apply network meta-analysis in clinical guidelines: A systematic review. |
| title_full_unstemmed | The impact of Cochrane Reviews that apply network meta-analysis in clinical guidelines: A systematic review. |
| title_short | The impact of Cochrane Reviews that apply network meta-analysis in clinical guidelines: A systematic review. |
| title_sort | impact of cochrane reviews that apply network meta analysis in clinical guidelines a systematic review |
| url | https://doi.org/10.1371/journal.pone.0315563 |
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