The impact of low-dose Fructooligosaccharide combined with Mesalazine on inflammation levels and therapeutic effects in elderly patients with ulcerative colitis
[Objective] To analyze the therapeutic effects, inflammation levels, and safety evaluation of low-dose Fructooligosaccharide combined with Mesalazine in elderly patients with ulcerative colitis. [Methods] Ninety elderly patients with ulcerative colitis treated in the First teaching Hospital of Xinji...
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Editorial Office of International Journal of Geriatrics
2025-07-01
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| Series: | Guoji laonian yixue zazhi |
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| Online Access: | http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.04.004&lang=en |
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| _version_ | 1839629002183016448 |
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| author | Wang Fangfang Ji Xiaoyan Li Chunhua Cui Min |
| author_facet | Wang Fangfang Ji Xiaoyan Li Chunhua Cui Min |
| author_sort | Wang Fangfang |
| collection | DOAJ |
| description | [Objective] To analyze the therapeutic effects, inflammation levels, and safety evaluation of low-dose Fructooligosaccharide combined with Mesalazine in elderly patients with ulcerative colitis. [Methods] Ninety elderly patients with ulcerative colitis treated in the First teaching Hospital of Xinjiang Medical University from January 2021 to January 2023 were included and randomly divided into a treatment group and a control group, with 45 patients in each. Both groups received routine treatment upon admission and oral Mesalazine enteric-coated tablets. The treatment group additionally received low-dose Fructooligosaccharide oral solution for 4 weeks. Therapeutic effects, levels of high-sensitivity C reactive protein (hs-CRP), interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α) in serum, and incidence of adverse reactions such as nausea, vomiting, and skin itching were compared. [Results] The total effective rate in the treatment group was 88.89%(40/45), it was significantly higher than the 64.44%(29/45) in the control group (P<0.05). There was no significant difference in hs-CRP, IL-8, and TNF-α levels between the two groups before treatment (P>0.05). After treatment, inflammatory marker levels in the treatment group were significantly lower than those in the control group (P<0.05). The incidence of adverse reactions was 13.33% in the treatment group and 11.11% in the control group, with no significant difference between the two groups (P>0.05). [Conclusion] Low-dose Fructooligosaccharide combined with Mesalazine can significantly improve therapeutic effects and reduce inflammation in elderly patients with ulcerative colitis, with a high level of safety. |
| format | Article |
| id | doaj-art-f8b1ad5ed29d4d7ca1e6738a8e81a4ad |
| institution | Matheson Library |
| issn | 1674-7593 |
| language | zho |
| publishDate | 2025-07-01 |
| publisher | Editorial Office of International Journal of Geriatrics |
| record_format | Article |
| series | Guoji laonian yixue zazhi |
| spelling | doaj-art-f8b1ad5ed29d4d7ca1e6738a8e81a4ad2025-07-15T08:16:34ZzhoEditorial Office of International Journal of GeriatricsGuoji laonian yixue zazhi1674-75932025-07-0146440340610.3969/j.issn.1674-7593.2025.04.004The impact of low-dose Fructooligosaccharide combined with Mesalazine on inflammation levels and therapeutic effects in elderly patients with ulcerative colitisWang Fangfang0Ji Xiaoyan1Li Chunhua2Cui Min3Department of Digestive Diseases, Digestive Diseases Center, the First Teaching Hospital of Xinjiang Medical University, Urumqi 830000Department of Digestive Diseases, Digestive Diseases Center, the First Teaching Hospital of Xinjiang Medical University, Urumqi 830000Department of Digestive Diseases, Digestive Diseases Center, the First Teaching Hospital of Xinjiang Medical University, Urumqi 830000Department of Digestive Diseases, Digestive Diseases Center, the First Teaching Hospital of Xinjiang Medical University, Urumqi 830000[Objective] To analyze the therapeutic effects, inflammation levels, and safety evaluation of low-dose Fructooligosaccharide combined with Mesalazine in elderly patients with ulcerative colitis. [Methods] Ninety elderly patients with ulcerative colitis treated in the First teaching Hospital of Xinjiang Medical University from January 2021 to January 2023 were included and randomly divided into a treatment group and a control group, with 45 patients in each. Both groups received routine treatment upon admission and oral Mesalazine enteric-coated tablets. The treatment group additionally received low-dose Fructooligosaccharide oral solution for 4 weeks. Therapeutic effects, levels of high-sensitivity C reactive protein (hs-CRP), interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α) in serum, and incidence of adverse reactions such as nausea, vomiting, and skin itching were compared. [Results] The total effective rate in the treatment group was 88.89%(40/45), it was significantly higher than the 64.44%(29/45) in the control group (P<0.05). There was no significant difference in hs-CRP, IL-8, and TNF-α levels between the two groups before treatment (P>0.05). After treatment, inflammatory marker levels in the treatment group were significantly lower than those in the control group (P<0.05). The incidence of adverse reactions was 13.33% in the treatment group and 11.11% in the control group, with no significant difference between the two groups (P>0.05). [Conclusion] Low-dose Fructooligosaccharide combined with Mesalazine can significantly improve therapeutic effects and reduce inflammation in elderly patients with ulcerative colitis, with a high level of safety.http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.04.004&lang=enfructooligosaccharidemesalazineulcerative colitistherapeutic effectsinflammation levels |
| spellingShingle | Wang Fangfang Ji Xiaoyan Li Chunhua Cui Min The impact of low-dose Fructooligosaccharide combined with Mesalazine on inflammation levels and therapeutic effects in elderly patients with ulcerative colitis Guoji laonian yixue zazhi fructooligosaccharide mesalazine ulcerative colitis therapeutic effects inflammation levels |
| title | The impact of low-dose Fructooligosaccharide combined with Mesalazine on inflammation levels and therapeutic effects in elderly patients with ulcerative colitis |
| title_full | The impact of low-dose Fructooligosaccharide combined with Mesalazine on inflammation levels and therapeutic effects in elderly patients with ulcerative colitis |
| title_fullStr | The impact of low-dose Fructooligosaccharide combined with Mesalazine on inflammation levels and therapeutic effects in elderly patients with ulcerative colitis |
| title_full_unstemmed | The impact of low-dose Fructooligosaccharide combined with Mesalazine on inflammation levels and therapeutic effects in elderly patients with ulcerative colitis |
| title_short | The impact of low-dose Fructooligosaccharide combined with Mesalazine on inflammation levels and therapeutic effects in elderly patients with ulcerative colitis |
| title_sort | impact of low dose fructooligosaccharide combined with mesalazine on inflammation levels and therapeutic effects in elderly patients with ulcerative colitis |
| topic | fructooligosaccharide mesalazine ulcerative colitis therapeutic effects inflammation levels |
| url | http://gwll.publish.founderss.cn/thesisDetails#10.3969/j.issn.1674-7593.2025.04.004&lang=en |
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