Impact of virus-mediated bacterial interactions on acute gastroenteritis symptoms: A new scoring system for clinical assessment
Acute gastroenteritis (AGE) exerts a substantial healthcare burden and economic loss annually, mainly due to viral infections. The objective of the study was to elucidate the impact of the interactions between the AGE virus and gut microbiota on patient clinical symptoms, thereby facilitating the ea...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Virulence |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/21505594.2025.2529442 |
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| author | Zhangkai Xu Zishu Liu Yuxiang Zhao Jiang Chen Weibo Cui Wenjing Wan Zhendi Yu Qingyi Shao Youshi Liu Baolan Hu Dongqing Cheng |
| author_facet | Zhangkai Xu Zishu Liu Yuxiang Zhao Jiang Chen Weibo Cui Wenjing Wan Zhendi Yu Qingyi Shao Youshi Liu Baolan Hu Dongqing Cheng |
| author_sort | Zhangkai Xu |
| collection | DOAJ |
| description | Acute gastroenteritis (AGE) exerts a substantial healthcare burden and economic loss annually, mainly due to viral infections. The objective of the study was to elucidate the impact of the interactions between the AGE virus and gut microbiota on patient clinical symptoms, thereby facilitating the early diagnosis and treatment of AGE. Clinical information and fecal samples were collected from 289 AGE patients (exclude fungal, parasitic, and bacterial infections), of whom 23.5% were infected with AGE viruses. A scoring method was developed to assess the severity of virus-induced AGE in patients. The results indicate significant differences (p < 0.05 indicates a significant difference, as determined by Kruskal–Wallis test, p = 0.03) in clinical symptom scores among the None-virus, Single-virus, and Dual-virus group. The Single-virus (14.82) and Dual-virus (15.33) groups exhibited more severe clinical symptom, with scoring values higher than None-virus group (12.40). Although significant differences in microbial community composition were observed between the Single-virus and Dual-virus groups (as determined by Adonis analysis, Variation = 0.11, p = 0.034), the diversity index (e.g. Chao1) did not significantly differ among the None-virus (288.14), Single-virus (345.74), and Dual-virus (282.70) groups. Notably, the patients with a higher Prevotella/Bacteroides index displayed more severe clinical symptom, as the index in the Single-virus and Dual-virus groups was over 10-times greater than in the None-virus group. In summary, this study shows that clinical symptoms of patients with viral AGE could be exacerbated through promoting bacterial competitions, and this understanding would facilitate the early diagnosis and treatment of viral AGE. |
| format | Article |
| id | doaj-art-f86e7b14e46c44bbba296d24251caa32 |
| institution | Matheson Library |
| issn | 2150-5594 2150-5608 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Virulence |
| spelling | doaj-art-f86e7b14e46c44bbba296d24251caa322025-07-14T05:57:13ZengTaylor & Francis GroupVirulence2150-55942150-56082025-12-0116110.1080/21505594.2025.2529442Impact of virus-mediated bacterial interactions on acute gastroenteritis symptoms: A new scoring system for clinical assessmentZhangkai Xu0Zishu Liu1Yuxiang Zhao2Jiang Chen3Weibo Cui4Wenjing Wan5Zhendi Yu6Qingyi Shao7Youshi Liu8Baolan Hu9Dongqing Cheng10School of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, ChinaCollege of Environmental and Resource Sciences, Zhejiang University, Hangzhou, ChinaCollege of Environmental and Resource Sciences, Zhejiang University, Hangzhou, ChinaSchool of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, ChinaSchool of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, ChinaThe Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, ChinaSchool of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, ChinaSchool of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, ChinaThe Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, ChinaCollege of Environmental and Resource Sciences, Zhejiang University, Hangzhou, ChinaSchool of Medical Technology and Information Engineering, Zhejiang Chinese Medical University, Hangzhou, ChinaAcute gastroenteritis (AGE) exerts a substantial healthcare burden and economic loss annually, mainly due to viral infections. The objective of the study was to elucidate the impact of the interactions between the AGE virus and gut microbiota on patient clinical symptoms, thereby facilitating the early diagnosis and treatment of AGE. Clinical information and fecal samples were collected from 289 AGE patients (exclude fungal, parasitic, and bacterial infections), of whom 23.5% were infected with AGE viruses. A scoring method was developed to assess the severity of virus-induced AGE in patients. The results indicate significant differences (p < 0.05 indicates a significant difference, as determined by Kruskal–Wallis test, p = 0.03) in clinical symptom scores among the None-virus, Single-virus, and Dual-virus group. The Single-virus (14.82) and Dual-virus (15.33) groups exhibited more severe clinical symptom, with scoring values higher than None-virus group (12.40). Although significant differences in microbial community composition were observed between the Single-virus and Dual-virus groups (as determined by Adonis analysis, Variation = 0.11, p = 0.034), the diversity index (e.g. Chao1) did not significantly differ among the None-virus (288.14), Single-virus (345.74), and Dual-virus (282.70) groups. Notably, the patients with a higher Prevotella/Bacteroides index displayed more severe clinical symptom, as the index in the Single-virus and Dual-virus groups was over 10-times greater than in the None-virus group. In summary, this study shows that clinical symptoms of patients with viral AGE could be exacerbated through promoting bacterial competitions, and this understanding would facilitate the early diagnosis and treatment of viral AGE.https://www.tandfonline.com/doi/10.1080/21505594.2025.2529442Viral acute gastroenteritisclinical symptom scoring scalegut microbiotavirus-mediated bacterial interactionsPrevotella/Bacteroides index |
| spellingShingle | Zhangkai Xu Zishu Liu Yuxiang Zhao Jiang Chen Weibo Cui Wenjing Wan Zhendi Yu Qingyi Shao Youshi Liu Baolan Hu Dongqing Cheng Impact of virus-mediated bacterial interactions on acute gastroenteritis symptoms: A new scoring system for clinical assessment Virulence Viral acute gastroenteritis clinical symptom scoring scale gut microbiota virus-mediated bacterial interactions Prevotella/Bacteroides index |
| title | Impact of virus-mediated bacterial interactions on acute gastroenteritis symptoms: A new scoring system for clinical assessment |
| title_full | Impact of virus-mediated bacterial interactions on acute gastroenteritis symptoms: A new scoring system for clinical assessment |
| title_fullStr | Impact of virus-mediated bacterial interactions on acute gastroenteritis symptoms: A new scoring system for clinical assessment |
| title_full_unstemmed | Impact of virus-mediated bacterial interactions on acute gastroenteritis symptoms: A new scoring system for clinical assessment |
| title_short | Impact of virus-mediated bacterial interactions on acute gastroenteritis symptoms: A new scoring system for clinical assessment |
| title_sort | impact of virus mediated bacterial interactions on acute gastroenteritis symptoms a new scoring system for clinical assessment |
| topic | Viral acute gastroenteritis clinical symptom scoring scale gut microbiota virus-mediated bacterial interactions Prevotella/Bacteroides index |
| url | https://www.tandfonline.com/doi/10.1080/21505594.2025.2529442 |
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