Study on the value of urinary albumin to total protein ratio in localizing childhood renal diseases
ObjectiveTo explore the diagnostic value of urinary albumin to total protein ratio （UAPR） in the morning urine and 24-h urine in localizing childhood renal diseases.MethodsA total of 98 children with proteinuria and renal diseases who were admitted to Ningxia Women and Children's Hospital， Peki...
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| 主要な著者: | , , , , |
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| フォーマット: | 論文 |
| 言語: | 中国語 |
| 出版事項: |
Editorial Department of Journal of Clinical Nephrology
2025-07-01
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| シリーズ: | Linchuang shenzangbing zazhi |
| 主題: | |
| オンライン･アクセス: | http://www.lcszb.com/thesisDetails#10.3969/j.issn.1671-2390.2025.07.005 |
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| 要約: | ObjectiveTo explore the diagnostic value of urinary albumin to total protein ratio （UAPR） in the morning urine and 24-h urine in localizing childhood renal diseases.MethodsA total of 98 children with proteinuria and renal diseases who were admitted to Ningxia Women and Children's Hospital， Peking University First Hospital from January 2022 to June 2024 were enrolled， including 90 cases of glomerular diseases （nephrotic syndrome， IgA nephropathy， purpura nephritis， lupus nephritis， and Alport syndrome）， and 8 cases of tubular diseases （8 acute tubulointerstitial nephritis and Dent's disease）. Based on clinical hematuria and proteinuria， children were assigned into four groups： Group A （gross hematuria group）， Group B （microscopic hematuria and non-nephrotic level proteinuria group）， Group C （nephrotic syndrome group）， and Group D （renal tubulointerstitial disease group with proteinuria）. Morning and 24-hour UAPR， urinary albumin/creatinine ratio， total protein/creatinine， and early renal injury indicators were tested.ResultsThirty children were selected in each of groups A， B， and C， and 8 children were selected in group D. Children in Group A had an UAPR of 0.52-0.53， including 12 （40%）cases with UAPR<0.5. Children in Group B had an UAPR of 0.45-0.48， including 15 （50%） cases with UAPR<0.5. Children in Group C had an UAPR of 0.74-0.75， including 30 （100%）cases with UAPR>0.5. Children in Group D had an UAPR of 0.30-0.31， including 8 （100%） cases with UAPR<0.5. There was a negative correlation between UAPR and α1-microglobulin/microalbumin in group D （<italic>r</italic>=-0.921~-0.947， <italic>P</italic><0.01）.ConclusionMorning urine or 24-hour UAPR both can be used as one of the location criteria for renal proteinuria in children. When hematuria is presented， UAPR<0.5 indicates hemoglobinuria； when no hematuria is presented， UAPR<0.5 indicates low molecule proteinuria. UAPR>0.5 indicates albuminuria in any conditions. |
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| ISSN: | 1671-2390 |