Individualisation of the Dose of Letrozole for Ovulation Induction in Infertile Women with Polycystic Ovary Syndrome Based on Clinical and Ultrasonography Criteria: A Cohort Study
Background: Conventionally, letrozole for ovulation induction (OI) in polycystic ovary syndrome (PCOS) is started at a dose of 2.5 mg, which is gradually escalated depending on the follicular response. The minimum dose required for follicular response for a particular patient is yet to be determined...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Journal of Human Reproductive Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jhrs.jhrs_72_25 |
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| author | Pratyasha Peepal Padmalaya Thakur Anubhuti Patel Jyotiranjan Sahoo Sujata Pradhan Manisha Sahu |
| author_facet | Pratyasha Peepal Padmalaya Thakur Anubhuti Patel Jyotiranjan Sahoo Sujata Pradhan Manisha Sahu |
| author_sort | Pratyasha Peepal |
| collection | DOAJ |
| description | Background:
Conventionally, letrozole for ovulation induction (OI) in polycystic ovary syndrome (PCOS) is started at a dose of 2.5 mg, which is gradually escalated depending on the follicular response. The minimum dose required for follicular response for a particular patient is yet to be determined.
Aim:
The aim of the study was to compare various clinical and ultrasonographic characteristics of patients with successful OI with different doses of letrozole and individualise the dose of letrozole.
Setting and Design:
This prospective cohort study was conducted in a tertiary care teaching hospital from December 2019 to March 2024.
Materials and Methods:
Ninety-seven patients were treated with a starting dose of 2.5 mg of letrozole. The dose was increased to 5 and 7.5 mg without a follicular response. Various clinical and ultrasonographic characteristics were compared.
Statistical Analysis Used:
Data entered in Microsoft Excel and analysed using SPSS version 27. P < 0.05 was statistically significant.
Results:
Of 97 patients, 10 were lost to follow-up. Eighty-one (93.1%) patients had a positive response to letrozole. Six (6.9%) patients did not respond to the maximum dose of 7.5 mg of letrozole. Waist circumference, maximum antral follicle count per ovary and volume of the largest ovary were significantly different for patients who responded to different doses of letrozole (P < 0.05). Further analysis revealed that an ovarian volume of 10 cc or more is a risk factor for non-response to 2.5 mg of letrozole.
Conclusion:
The ovarian volume can be considered when determining the dose of letrozole in PCOS. |
| format | Article |
| id | doaj-art-f84e00c20cd04fe496cd91e1a3180b49 |
| institution | Matheson Library |
| issn | 0974-1208 1998-4766 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Human Reproductive Sciences |
| spelling | doaj-art-f84e00c20cd04fe496cd91e1a3180b492025-07-04T08:45:57ZengWolters Kluwer Medknow PublicationsJournal of Human Reproductive Sciences0974-12081998-47662025-04-01182899510.4103/jhrs.jhrs_72_25Individualisation of the Dose of Letrozole for Ovulation Induction in Infertile Women with Polycystic Ovary Syndrome Based on Clinical and Ultrasonography Criteria: A Cohort StudyPratyasha PeepalPadmalaya ThakurAnubhuti PatelJyotiranjan SahooSujata PradhanManisha SahuBackground: Conventionally, letrozole for ovulation induction (OI) in polycystic ovary syndrome (PCOS) is started at a dose of 2.5 mg, which is gradually escalated depending on the follicular response. The minimum dose required for follicular response for a particular patient is yet to be determined. Aim: The aim of the study was to compare various clinical and ultrasonographic characteristics of patients with successful OI with different doses of letrozole and individualise the dose of letrozole. Setting and Design: This prospective cohort study was conducted in a tertiary care teaching hospital from December 2019 to March 2024. Materials and Methods: Ninety-seven patients were treated with a starting dose of 2.5 mg of letrozole. The dose was increased to 5 and 7.5 mg without a follicular response. Various clinical and ultrasonographic characteristics were compared. Statistical Analysis Used: Data entered in Microsoft Excel and analysed using SPSS version 27. P < 0.05 was statistically significant. Results: Of 97 patients, 10 were lost to follow-up. Eighty-one (93.1%) patients had a positive response to letrozole. Six (6.9%) patients did not respond to the maximum dose of 7.5 mg of letrozole. Waist circumference, maximum antral follicle count per ovary and volume of the largest ovary were significantly different for patients who responded to different doses of letrozole (P < 0.05). Further analysis revealed that an ovarian volume of 10 cc or more is a risk factor for non-response to 2.5 mg of letrozole. Conclusion: The ovarian volume can be considered when determining the dose of letrozole in PCOS.https://journals.lww.com/10.4103/jhrs.jhrs_72_25individualisationletrozoleovulation inductionpolycystic ovary syndromeultrasonography criteria |
| spellingShingle | Pratyasha Peepal Padmalaya Thakur Anubhuti Patel Jyotiranjan Sahoo Sujata Pradhan Manisha Sahu Individualisation of the Dose of Letrozole for Ovulation Induction in Infertile Women with Polycystic Ovary Syndrome Based on Clinical and Ultrasonography Criteria: A Cohort Study Journal of Human Reproductive Sciences individualisation letrozole ovulation induction polycystic ovary syndrome ultrasonography criteria |
| title | Individualisation of the Dose of Letrozole for Ovulation Induction in Infertile Women with Polycystic Ovary Syndrome Based on Clinical and Ultrasonography Criteria: A Cohort Study |
| title_full | Individualisation of the Dose of Letrozole for Ovulation Induction in Infertile Women with Polycystic Ovary Syndrome Based on Clinical and Ultrasonography Criteria: A Cohort Study |
| title_fullStr | Individualisation of the Dose of Letrozole for Ovulation Induction in Infertile Women with Polycystic Ovary Syndrome Based on Clinical and Ultrasonography Criteria: A Cohort Study |
| title_full_unstemmed | Individualisation of the Dose of Letrozole for Ovulation Induction in Infertile Women with Polycystic Ovary Syndrome Based on Clinical and Ultrasonography Criteria: A Cohort Study |
| title_short | Individualisation of the Dose of Letrozole for Ovulation Induction in Infertile Women with Polycystic Ovary Syndrome Based on Clinical and Ultrasonography Criteria: A Cohort Study |
| title_sort | individualisation of the dose of letrozole for ovulation induction in infertile women with polycystic ovary syndrome based on clinical and ultrasonography criteria a cohort study |
| topic | individualisation letrozole ovulation induction polycystic ovary syndrome ultrasonography criteria |
| url | https://journals.lww.com/10.4103/jhrs.jhrs_72_25 |
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