A Review of the Molecular Aggregation of Small-Molecule Anion Sensors for Environmental Contaminates in Aqueous Media

A primary challenge in the further development of anion sensors in real water samples of environmental concern is the need for highly water-soluble compounds that are able to detect low concentrations of analytes. Small-molecule sensors can mitigate solubility constraints and highly aromatic or conj...

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Bibliographic Details
Main Authors: Mallory E. Thomas, Alistair J. Lees
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Sustainable Chemistry
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Online Access:https://www.mdpi.com/2673-4079/6/2/17
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Summary:A primary challenge in the further development of anion sensors in real water samples of environmental concern is the need for highly water-soluble compounds that are able to detect low concentrations of analytes. Small-molecule sensors can mitigate solubility constraints and highly aromatic or conjugated systems may provide a new way to recognize target analytes with high sensitivity and/or selectivity. Organic aggregates that have the ability to form large frameworks can exhibit aggregated-induced emissions to detect target analytes, and their coagulation can provide enhanced detection via colorimetric or fluorescent measurements. This review aims to draw attention to the emerging area of small-molecule organic chemosensors that utilize aggregation to detect environmentally detrimental anions in an aqueous solution. A number of mechanisms of interaction for anion recognition are recognized and discussed here, including electrostatic interactions, covalent bond formation, hydrophobic interactions, and even complexation.
ISSN:2673-4079