Two Cases of Statin-Induced Immune-Mediated Necrotizing Myopathy: A Rare Side Effect of Statins
Statins are effective drugs for lowering cholesterol and reducing cardiovascular risk. Rarely, they can trigger autoimmune myopathies like immune-mediated necrotizing myopathy (IMNM), associated with anti-HMGCR antibodies. This condition may persist after statin discontinuation and requires immunosu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-06-01
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| Series: | Rheumato |
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| Online Access: | https://www.mdpi.com/2674-0621/5/2/7 |
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| _version_ | 1839652808313274368 |
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| author | Luis Angel Montero Furelos Clara Fernandez Peña Beatriz San Millan Tejedor |
| author_facet | Luis Angel Montero Furelos Clara Fernandez Peña Beatriz San Millan Tejedor |
| author_sort | Luis Angel Montero Furelos |
| collection | DOAJ |
| description | Statins are effective drugs for lowering cholesterol and reducing cardiovascular risk. Rarely, they can trigger autoimmune myopathies like immune-mediated necrotizing myopathy (IMNM), associated with anti-HMGCR antibodies. This condition may persist after statin discontinuation and requires immunosuppressive treatment. Despite these rare side effects, the benefits of statins outweigh the risks for most patients. |
| format | Article |
| id | doaj-art-f7b890fe8a794de883d2d1d3ca3b6ea9 |
| institution | Matheson Library |
| issn | 2674-0621 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Rheumato |
| spelling | doaj-art-f7b890fe8a794de883d2d1d3ca3b6ea92025-06-25T14:24:28ZengMDPI AGRheumato2674-06212025-06-0152710.3390/rheumato5020007Two Cases of Statin-Induced Immune-Mediated Necrotizing Myopathy: A Rare Side Effect of StatinsLuis Angel Montero Furelos0Clara Fernandez Peña1Beatriz San Millan Tejedor2Orthopedic Surgery and Traumatology Service, Hip Unit, Santiago de Compostela University Clinical Hospital, SERGAS, 15706 Santiago de Compostela, SpainDepartment Internal Medicine, Santiago de Compostela University Clinical Hospital, SERGAS, 15706 Santiago de Compostela, SpainDepartment Anatomo Pathology, Hospital Alvaro Cunqueiro, SERGAS, 36312 Vigo, SpainStatins are effective drugs for lowering cholesterol and reducing cardiovascular risk. Rarely, they can trigger autoimmune myopathies like immune-mediated necrotizing myopathy (IMNM), associated with anti-HMGCR antibodies. This condition may persist after statin discontinuation and requires immunosuppressive treatment. Despite these rare side effects, the benefits of statins outweigh the risks for most patients.https://www.mdpi.com/2674-0621/5/2/7immune-mediated necrotizing myopathystatinsautoimmune myopathies |
| spellingShingle | Luis Angel Montero Furelos Clara Fernandez Peña Beatriz San Millan Tejedor Two Cases of Statin-Induced Immune-Mediated Necrotizing Myopathy: A Rare Side Effect of Statins Rheumato immune-mediated necrotizing myopathy statins autoimmune myopathies |
| title | Two Cases of Statin-Induced Immune-Mediated Necrotizing Myopathy: A Rare Side Effect of Statins |
| title_full | Two Cases of Statin-Induced Immune-Mediated Necrotizing Myopathy: A Rare Side Effect of Statins |
| title_fullStr | Two Cases of Statin-Induced Immune-Mediated Necrotizing Myopathy: A Rare Side Effect of Statins |
| title_full_unstemmed | Two Cases of Statin-Induced Immune-Mediated Necrotizing Myopathy: A Rare Side Effect of Statins |
| title_short | Two Cases of Statin-Induced Immune-Mediated Necrotizing Myopathy: A Rare Side Effect of Statins |
| title_sort | two cases of statin induced immune mediated necrotizing myopathy a rare side effect of statins |
| topic | immune-mediated necrotizing myopathy statins autoimmune myopathies |
| url | https://www.mdpi.com/2674-0621/5/2/7 |
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