Present Strategy and Tactics of Antibacterial Therapy for Hospital Infections: Lessons Learned from the COVID-19 Pandemic
A significant increase in sales of antibacterial drugs in pharmacies and their purchases by medical institutions of the Russian Healthcare System was observed against the background of the past pandemic of a novel coronavirus infection in Russia. Microbiological monitoring that was carried out at Ci...
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| Language: | Russian |
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LLC "Publishing House OKI"
2024-01-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/1081 |
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| author | S. D. Mitrokhin A. V. Aleshkin A. A. Galitskiy A. S. Shkoda |
| author_facet | S. D. Mitrokhin A. V. Aleshkin A. A. Galitskiy A. S. Shkoda |
| author_sort | S. D. Mitrokhin |
| collection | DOAJ |
| description | A significant increase in sales of antibacterial drugs in pharmacies and their purchases by medical institutions of the Russian Healthcare System was observed against the background of the past pandemic of a novel coronavirus infection in Russia. Microbiological monitoring that was carried out at City Clinical Hospital No. 67 named after. L. A. Vorokhobov (Moscow) in 2020–2021, revealed a pressing problem — primarily gram-negative bacteria, with a predominance of multidrug-resistant (MDR) strains, were isolated from patients with healthcare-associated infections (HAIs). As shown by pharmacoeconomic studies conducted by the authors, the cost of one course of targeted antibacterial therapy for HAI in this case could increase by 6–12 times compared to a similar course of therapy in the absence of both MDR strains and XDR strains of hospital pathogens. In order to achieve a reduction in the cost of antibacterial therapy developed and used by the authors, in addition to the development of effective antibacterial therapy regimens for HAIs caused by MDR/XDR pathogens, another study was carried out as a continuation of the work on creating and improving biotherapy regimens for HAIs, namely the development of personalized phage therapy regimens for patients with hospital-acquired pneumonia caused by MDR bacterial strains. Based on the data obtained, the concept of a personalized approach to phage therapy of various nosological forms of HAIs caused by hospital-acquired MDR pathogens in patients of a multidisciplinary hospital was proposed and tested. As a result of this approach, the effectiveness of phage therapy for various nosological forms of HAIs caused by MDR and XDR strains of hospital pathogens in City Clinical Hospital No. 67 named after. L. A. Vorokhobov increased by 30%, and the effectiveness of the initial antibiotic regimen was 70%. The economic effect of the combination of antibiotic therapy and phage therapy («booster therapy») amounted to 3,000,000 rubles, compared with the use of antibiotics alone in the treatment of patients with HAIs caused by MDR/XDR strains of hospital pathogens. |
| format | Article |
| id | doaj-art-f77fe14239e34d13a60c0b5c512f4f6a |
| institution | Matheson Library |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2024-01-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-f77fe14239e34d13a60c0b5c512f4f6a2025-08-03T13:04:50ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902024-01-01689-10727810.37489/0235-2990-2022-67-9-10-72-78997Present Strategy and Tactics of Antibacterial Therapy for Hospital Infections: Lessons Learned from the COVID-19 PandemicS. D. Mitrokhin0A. V. Aleshkin1A. A. Galitskiy2A. S. Shkoda3City Clinical Hospital No. 67 named after. L. A. Vorokhobov, Moscow Health DepartmentG. N. Gabrichevsky Moscow Scientific Research Institute of Epidemiology and Microbiology of RospotrebnadzorCity Clinical Hospital No. 67 named after. L. A. Vorokhobov, Moscow Health Department; G. N. Gabrichevsky Moscow Scientific Research Institute of Epidemiology and Microbiology of RospotrebnadzorCity Clinical Hospital No. 67 named after. L. A. Vorokhobov, Moscow Health DepartmentA significant increase in sales of antibacterial drugs in pharmacies and their purchases by medical institutions of the Russian Healthcare System was observed against the background of the past pandemic of a novel coronavirus infection in Russia. Microbiological monitoring that was carried out at City Clinical Hospital No. 67 named after. L. A. Vorokhobov (Moscow) in 2020–2021, revealed a pressing problem — primarily gram-negative bacteria, with a predominance of multidrug-resistant (MDR) strains, were isolated from patients with healthcare-associated infections (HAIs). As shown by pharmacoeconomic studies conducted by the authors, the cost of one course of targeted antibacterial therapy for HAI in this case could increase by 6–12 times compared to a similar course of therapy in the absence of both MDR strains and XDR strains of hospital pathogens. In order to achieve a reduction in the cost of antibacterial therapy developed and used by the authors, in addition to the development of effective antibacterial therapy regimens for HAIs caused by MDR/XDR pathogens, another study was carried out as a continuation of the work on creating and improving biotherapy regimens for HAIs, namely the development of personalized phage therapy regimens for patients with hospital-acquired pneumonia caused by MDR bacterial strains. Based on the data obtained, the concept of a personalized approach to phage therapy of various nosological forms of HAIs caused by hospital-acquired MDR pathogens in patients of a multidisciplinary hospital was proposed and tested. As a result of this approach, the effectiveness of phage therapy for various nosological forms of HAIs caused by MDR and XDR strains of hospital pathogens in City Clinical Hospital No. 67 named after. L. A. Vorokhobov increased by 30%, and the effectiveness of the initial antibiotic regimen was 70%. The economic effect of the combination of antibiotic therapy and phage therapy («booster therapy») amounted to 3,000,000 rubles, compared with the use of antibiotics alone in the treatment of patients with HAIs caused by MDR/XDR strains of hospital pathogens.https://www.antibiotics-chemotherapy.ru/jour/article/view/1081haimdr hospital strainspersonalized phage therapycombined antibiotic/phage therapy for hais |
| spellingShingle | S. D. Mitrokhin A. V. Aleshkin A. A. Galitskiy A. S. Shkoda Present Strategy and Tactics of Antibacterial Therapy for Hospital Infections: Lessons Learned from the COVID-19 Pandemic Антибиотики и Химиотерапия hai mdr hospital strains personalized phage therapy combined antibiotic/phage therapy for hais |
| title | Present Strategy and Tactics of Antibacterial Therapy for Hospital Infections: Lessons Learned from the COVID-19 Pandemic |
| title_full | Present Strategy and Tactics of Antibacterial Therapy for Hospital Infections: Lessons Learned from the COVID-19 Pandemic |
| title_fullStr | Present Strategy and Tactics of Antibacterial Therapy for Hospital Infections: Lessons Learned from the COVID-19 Pandemic |
| title_full_unstemmed | Present Strategy and Tactics of Antibacterial Therapy for Hospital Infections: Lessons Learned from the COVID-19 Pandemic |
| title_short | Present Strategy and Tactics of Antibacterial Therapy for Hospital Infections: Lessons Learned from the COVID-19 Pandemic |
| title_sort | present strategy and tactics of antibacterial therapy for hospital infections lessons learned from the covid 19 pandemic |
| topic | hai mdr hospital strains personalized phage therapy combined antibiotic/phage therapy for hais |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/1081 |
| work_keys_str_mv | AT sdmitrokhin presentstrategyandtacticsofantibacterialtherapyforhospitalinfectionslessonslearnedfromthecovid19pandemic AT avaleshkin presentstrategyandtacticsofantibacterialtherapyforhospitalinfectionslessonslearnedfromthecovid19pandemic AT aagalitskiy presentstrategyandtacticsofantibacterialtherapyforhospitalinfectionslessonslearnedfromthecovid19pandemic AT asshkoda presentstrategyandtacticsofantibacterialtherapyforhospitalinfectionslessonslearnedfromthecovid19pandemic |