Combination of Neoadjuvant Gemcitabine‐Cisplatin and Anti‐Tuberculosis Therapy for a Patient With Muscle‐Invasive Bladder Cancer and Renal Granulomatosis That Progressed After Intravesical Bacillus Calmette‐Guérin Therapy

Combination of Neoadjuvant Gemcitabine‐Cisplatin and Anti‐Tuberculosis Therapy for a Patient With Muscle‐Invasive Bladder Cancer and Renal Granulomatosis That Progressed After Intravesical Bacillus Calmette‐Guérin Therapy

ABSTRACT Introduction A case of muscle‐invasive bladder cancer and renal granulomatosis that developed after intravesical Bacillus Calmette‐Guérin therapy, in which a combination of neoadjuvant gemcitabine‐cisplatin and anti‐tuberculosis therapy was safely administered, and radical cystectomy was ul...

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Main Authors: Takahiro Tsumori, Seiji Hoshi, Kei Yaginuma, Satoru Meguro, Kanako Matsuoka, Junya Hata, Yuichi Sato, Hidenori Akaihata, Soichiro Ogawa, Yoshiyuki Kojima
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:IJU Case Reports
Subjects:
anti‐tuberculosis therapy
Bacillus Calmette‐Guérin
bladder cancer
neoadjuvant chemotherapy
renal granulomas
Online Access:https://doi.org/10.1002/iju5.70057
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Summary:ABSTRACT Introduction A case of muscle‐invasive bladder cancer and renal granulomatosis that developed after intravesical Bacillus Calmette‐Guérin therapy, in which a combination of neoadjuvant gemcitabine‐cisplatin and anti‐tuberculosis therapy was safely administered, and radical cystectomy was ultimately performed, is reported. Case Presentation A 64‐year‐old man with non‐muscle‐invasive bladder cancer underwent transurethral resection and intravesical Bacillus Calmette‐Guérin therapy every time bladder cancer recurred. However, the patient developed left renal granulomatosis during treatment. Anti‐tuberculosis therapy was prioritized since there was no bladder cancer progression. However, local bladder cancer progression was observed during the anti‐tuberculosis therapy. To successfully cure the renal granulomatosis and suppress tumor progression, neoadjuvant gemcitabine‐cisplatin was combined with anti‐tuberculosis therapy for 2 months, followed by radical cystectomy. There were no gemcitabine‐cisplatin complications and no renal granulomatosis recurrence during combination therapy. Conclusion Combination of gemcitabine‐cisplatin and anti‐tuberculosis therapy was possible for a patient with bladder cancer when Bacillus Calmette‐Guérin infection was under control.
ISSN:2577-171X

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