HEREDITARY DIFFUSE GASTRIC CANCER: GENETIC ASPECTS AND PROPHYLACTIC TOTAL GASTRECTOMY
For patients with an identified germline E-cadherin-1 (CDH1) mutation, prophylactic gastrectomy is the treatment of choice to eliminate the high risk of developing diffuse gastric cancer. The case report describes a rare case of hereditary diffuse gastric cancer (HDGC) associated with CDH1 gene mu...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2018-09-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/815 |
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| author | L. N. Lyubchenko M. G. Filippova O. A. Anurova P. B. Nazliev I. S. Stilidi |
| author_facet | L. N. Lyubchenko M. G. Filippova O. A. Anurova P. B. Nazliev I. S. Stilidi |
| author_sort | L. N. Lyubchenko |
| collection | DOAJ |
| description | For patients with an identified germline E-cadherin-1 (CDH1) mutation, prophylactic gastrectomy is the treatment of choice to eliminate the high risk of developing diffuse gastric cancer. The case report describes a rare case of hereditary diffuse gastric cancer (HDGC) associated with CDH1 gene mutation, which is reported in the Russian population for the first time. In 2013, a 28-year- old woman was referred to Clinical Oncogenetics Laboratory with a family history of gastric cancer. Molecular genetic analysis revealed CDH1 gene mutation. The lifetime risk of cancer in mutation positive members is more than 80. Histological examination of gastric biopsy specimens obtained during endoscopy revealed isolated signet ring cells in the lamina propria. Spleenpreserving D2-lymphodissection and total gastrectomy with Roux-en-Y reconstruction with a jejunal reservoir formation were performed at the Abdominal Oncology Surgery Department. |
| format | Article |
| id | doaj-art-f70d94e4a0c54e638b085d8c70b36a03 |
| institution | Matheson Library |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2018-09-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-f70d94e4a0c54e638b085d8c70b36a032025-08-04T10:33:38ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682018-09-01174485210.21294/1814-4861-2018-17-4-48-52561HEREDITARY DIFFUSE GASTRIC CANCER: GENETIC ASPECTS AND PROPHYLACTIC TOTAL GASTRECTOMYL. N. Lyubchenko0M. G. Filippova1O. A. Anurova2P. B. Nazliev3I. S. Stilidi4N.N. Blokhin Medical Research Center of Oncology, Ministry of Health of the Russian FederationN.N. Blokhin Medical Research Center of Oncology, Ministry of Health of the Russian FederationN.N. Blokhin Medical Research Center of Oncology, Ministry of Health of the Russian FederationN.N. Blokhin Medical Research Center of Oncology, Ministry of Health of the Russian FederationN.N. Blokhin Medical Research Center of Oncology, Ministry of Health of the Russian FederationFor patients with an identified germline E-cadherin-1 (CDH1) mutation, prophylactic gastrectomy is the treatment of choice to eliminate the high risk of developing diffuse gastric cancer. The case report describes a rare case of hereditary diffuse gastric cancer (HDGC) associated with CDH1 gene mutation, which is reported in the Russian population for the first time. In 2013, a 28-year- old woman was referred to Clinical Oncogenetics Laboratory with a family history of gastric cancer. Molecular genetic analysis revealed CDH1 gene mutation. The lifetime risk of cancer in mutation positive members is more than 80. Histological examination of gastric biopsy specimens obtained during endoscopy revealed isolated signet ring cells in the lamina propria. Spleenpreserving D2-lymphodissection and total gastrectomy with Roux-en-Y reconstruction with a jejunal reservoir formation were performed at the Abdominal Oncology Surgery Department.https://www.siboncoj.ru/jour/article/view/815hereditary diffuse gastric cancer (hdgc)cdh1 genegastrectomymolecular genetic diagnostics |
| spellingShingle | L. N. Lyubchenko M. G. Filippova O. A. Anurova P. B. Nazliev I. S. Stilidi HEREDITARY DIFFUSE GASTRIC CANCER: GENETIC ASPECTS AND PROPHYLACTIC TOTAL GASTRECTOMY Сибирский онкологический журнал hereditary diffuse gastric cancer (hdgc) cdh1 gene gastrectomy molecular genetic diagnostics |
| title | HEREDITARY DIFFUSE GASTRIC CANCER: GENETIC ASPECTS AND PROPHYLACTIC TOTAL GASTRECTOMY |
| title_full | HEREDITARY DIFFUSE GASTRIC CANCER: GENETIC ASPECTS AND PROPHYLACTIC TOTAL GASTRECTOMY |
| title_fullStr | HEREDITARY DIFFUSE GASTRIC CANCER: GENETIC ASPECTS AND PROPHYLACTIC TOTAL GASTRECTOMY |
| title_full_unstemmed | HEREDITARY DIFFUSE GASTRIC CANCER: GENETIC ASPECTS AND PROPHYLACTIC TOTAL GASTRECTOMY |
| title_short | HEREDITARY DIFFUSE GASTRIC CANCER: GENETIC ASPECTS AND PROPHYLACTIC TOTAL GASTRECTOMY |
| title_sort | hereditary diffuse gastric cancer genetic aspects and prophylactic total gastrectomy |
| topic | hereditary diffuse gastric cancer (hdgc) cdh1 gene gastrectomy molecular genetic diagnostics |
| url | https://www.siboncoj.ru/jour/article/view/815 |
| work_keys_str_mv | AT lnlyubchenko hereditarydiffusegastriccancergeneticaspectsandprophylactictotalgastrectomy AT mgfilippova hereditarydiffusegastriccancergeneticaspectsandprophylactictotalgastrectomy AT oaanurova hereditarydiffusegastriccancergeneticaspectsandprophylactictotalgastrectomy AT pbnazliev hereditarydiffusegastriccancergeneticaspectsandprophylactictotalgastrectomy AT isstilidi hereditarydiffusegastriccancergeneticaspectsandprophylactictotalgastrectomy |