Comparative Physicochemical and Pharmacotechnical Evaluation of Three Topical Gel-Cream Formulations
In the context of modern dermocosmetic development, multifunctional topical gel-cream formulations must be efficient for both therapeutic efficacy and cosmetic applications. This study presents a comparative physicochemical and pharmacotechnical analysis of three topical gel-cream formulations devel...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-07-01
|
| Series: | Gels |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2310-2861/11/7/532 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839615962194640896 |
|---|---|
| author | Ramona Pârvănescu Cristina Trandafirescu Adina Magdalena Musuc Emma Adriana Ozon Daniela C. Culita Raul-Augustin Mitran Cristina-Ionela Stănciulescu Codruța Șoica |
| author_facet | Ramona Pârvănescu Cristina Trandafirescu Adina Magdalena Musuc Emma Adriana Ozon Daniela C. Culita Raul-Augustin Mitran Cristina-Ionela Stănciulescu Codruța Șoica |
| author_sort | Ramona Pârvănescu |
| collection | DOAJ |
| description | In the context of modern dermocosmetic development, multifunctional topical gel-cream formulations must be efficient for both therapeutic efficacy and cosmetic applications. This study presents a comparative physicochemical and pharmacotechnical analysis of three topical gel-cream formulations developed by Brand Chanand<sup>®</sup>: Acne Control Cleanser (ACC), Acne Face Cream (AFC), and Gentle Cream Cleanser Serum Control, Regenerating, Hydrating, Calming (IRC). Each formulation is enriched with a specific blend of bioactive compounds, including botanical oils, vitamins, and proteins, designed to treat acne, to support skin regeneration, and to maintain the skin barrier. A multidisciplinary approach was used, including Fourier Transform Infrared Spectroscopy with Attenuated Total Reflectance (FTIR-ATR), differential scanning calorimetry (DSC), rheological evaluation, pH and density determination, spreadability analysis, and oxidative stability testing to evaluate the products. Antioxidant capacity was assessed through multiple in vitro assays. The results demonstrated that all three gel-cream formulations exhibit pseudoplastic rheological behaviour, suitable for topical application. AFC showed the highest oxidative stability and antioxidant activity, while IRC presented superior spreadability and cosmetic efficacy, likely due to its complex composition. ACC displayed faster absorption and was ideal for targeted use on oily or acne-prone skin. The differences observed in the stability and performance suggest that the ingredient synergy, base composition, and solubility profiles show notable variations in dermato-cosmetic formulations. These findings highlight the formulation–performance relationship in topical gel-cream formulations and support the development of new cosmetic products tailored for sensitive and acne-prone skin. |
| format | Article |
| id | doaj-art-f6f5209d7f4549b1b99b1e20a9eb7028 |
| institution | Matheson Library |
| issn | 2310-2861 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj-art-f6f5209d7f4549b1b99b1e20a9eb70282025-07-25T13:23:57ZengMDPI AGGels2310-28612025-07-0111753210.3390/gels11070532Comparative Physicochemical and Pharmacotechnical Evaluation of Three Topical Gel-Cream FormulationsRamona Pârvănescu0Cristina Trandafirescu1Adina Magdalena Musuc2Emma Adriana Ozon3Daniela C. Culita4Raul-Augustin Mitran5Cristina-Ionela Stănciulescu6Codruța Șoica7Department of Pharmaceutical Chemistry, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartment of Pharmaceutical Chemistry, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, RomaniaInstitute of Physical Chemistry—Ilie Murgulescu, Romanian Academy, 202 Spl. Independentei, 060021 Bucharest, RomaniaDepartment of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia St., 020956 Bucharest, RomaniaInstitute of Physical Chemistry—Ilie Murgulescu, Romanian Academy, 202 Spl. Independentei, 060021 Bucharest, RomaniaInstitute of Physical Chemistry—Ilie Murgulescu, Romanian Academy, 202 Spl. Independentei, 060021 Bucharest, RomaniaDermatology Department, Faculty of Medicine, University of Medicine and Pharmacy Craiova, 2 Petru Rares St., 200349 Craiova, RomaniaResearch Center for Experimental Pharmacology and Drug Design (X-Pharm Design), “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, RomaniaIn the context of modern dermocosmetic development, multifunctional topical gel-cream formulations must be efficient for both therapeutic efficacy and cosmetic applications. This study presents a comparative physicochemical and pharmacotechnical analysis of three topical gel-cream formulations developed by Brand Chanand<sup>®</sup>: Acne Control Cleanser (ACC), Acne Face Cream (AFC), and Gentle Cream Cleanser Serum Control, Regenerating, Hydrating, Calming (IRC). Each formulation is enriched with a specific blend of bioactive compounds, including botanical oils, vitamins, and proteins, designed to treat acne, to support skin regeneration, and to maintain the skin barrier. A multidisciplinary approach was used, including Fourier Transform Infrared Spectroscopy with Attenuated Total Reflectance (FTIR-ATR), differential scanning calorimetry (DSC), rheological evaluation, pH and density determination, spreadability analysis, and oxidative stability testing to evaluate the products. Antioxidant capacity was assessed through multiple in vitro assays. The results demonstrated that all three gel-cream formulations exhibit pseudoplastic rheological behaviour, suitable for topical application. AFC showed the highest oxidative stability and antioxidant activity, while IRC presented superior spreadability and cosmetic efficacy, likely due to its complex composition. ACC displayed faster absorption and was ideal for targeted use on oily or acne-prone skin. The differences observed in the stability and performance suggest that the ingredient synergy, base composition, and solubility profiles show notable variations in dermato-cosmetic formulations. These findings highlight the formulation–performance relationship in topical gel-cream formulations and support the development of new cosmetic products tailored for sensitive and acne-prone skin.https://www.mdpi.com/2310-2861/11/7/532gel-cream formulationsnatural cosmetic formulationsoxidative stabilityantioxidant capacityskin barrier function |
| spellingShingle | Ramona Pârvănescu Cristina Trandafirescu Adina Magdalena Musuc Emma Adriana Ozon Daniela C. Culita Raul-Augustin Mitran Cristina-Ionela Stănciulescu Codruța Șoica Comparative Physicochemical and Pharmacotechnical Evaluation of Three Topical Gel-Cream Formulations Gels gel-cream formulations natural cosmetic formulations oxidative stability antioxidant capacity skin barrier function |
| title | Comparative Physicochemical and Pharmacotechnical Evaluation of Three Topical Gel-Cream Formulations |
| title_full | Comparative Physicochemical and Pharmacotechnical Evaluation of Three Topical Gel-Cream Formulations |
| title_fullStr | Comparative Physicochemical and Pharmacotechnical Evaluation of Three Topical Gel-Cream Formulations |
| title_full_unstemmed | Comparative Physicochemical and Pharmacotechnical Evaluation of Three Topical Gel-Cream Formulations |
| title_short | Comparative Physicochemical and Pharmacotechnical Evaluation of Three Topical Gel-Cream Formulations |
| title_sort | comparative physicochemical and pharmacotechnical evaluation of three topical gel cream formulations |
| topic | gel-cream formulations natural cosmetic formulations oxidative stability antioxidant capacity skin barrier function |
| url | https://www.mdpi.com/2310-2861/11/7/532 |
| work_keys_str_mv | AT ramonaparvanescu comparativephysicochemicalandpharmacotechnicalevaluationofthreetopicalgelcreamformulations AT cristinatrandafirescu comparativephysicochemicalandpharmacotechnicalevaluationofthreetopicalgelcreamformulations AT adinamagdalenamusuc comparativephysicochemicalandpharmacotechnicalevaluationofthreetopicalgelcreamformulations AT emmaadrianaozon comparativephysicochemicalandpharmacotechnicalevaluationofthreetopicalgelcreamformulations AT danielacculita comparativephysicochemicalandpharmacotechnicalevaluationofthreetopicalgelcreamformulations AT raulaugustinmitran comparativephysicochemicalandpharmacotechnicalevaluationofthreetopicalgelcreamformulations AT cristinaionelastanciulescu comparativephysicochemicalandpharmacotechnicalevaluationofthreetopicalgelcreamformulations AT codrutasoica comparativephysicochemicalandpharmacotechnicalevaluationofthreetopicalgelcreamformulations |