Discovery of a selective dual-specificity tyrosine phosphorylation-regulated kinase 1B inhibitor with anti-adipogenic and anti-diabetic activities

Discovery of a selective dual-specificity tyrosine phosphorylation-regulated kinase 1B inhibitor with anti-adipogenic and anti-diabetic activities

BackgroundDual-specificity tyrosine phosphorylation-regulated kinase 1B (DYRK1B) is implicated in metabolic diseases, with high expression linked to adipocyte differentiation and metabolic disorders. This study investigated the anti-adipogenic and anti-diabetic effects of a novel selective DYRK1B in...

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Main Authors: Sein Kang, Yoon-Ju Na, Kyoung Jin Choi, Won Hoon Jung, Areum Park, Jeonghui Im, Sung Bum Park, Byumseok Koh, Joo-Youn Lee, Kwang-Lae Hoe, Heung Jae Kim, Sang Joon Shin, Hyuk Lee, Ki Young Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
DYRK1B
adipogenesis
obesity
type 2 diabetes
FOXO1A
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1645033/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1645033/full

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