Gut Microbiota and its Impact on Chronic Diseases: A Comprehensive Review
The intricate community of bacteria that live in the gastrointestinal system, known as the gut microbiota, is essential to preserving human health and equilibrium. The pathophysiology of several chronic illnesses, including as neurological, cardiovascular, immunological, and metabolic disorders, has...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-06-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_309_25 |
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| author | Sahil P. Patel Srushti J. Bhoraniya Shruti D. Kalola Atul Rukadikar Renju Ravi Samreen Farooqui Charushila Rukadikar |
| author_facet | Sahil P. Patel Srushti J. Bhoraniya Shruti D. Kalola Atul Rukadikar Renju Ravi Samreen Farooqui Charushila Rukadikar |
| author_sort | Sahil P. Patel |
| collection | DOAJ |
| description | The intricate community of bacteria that live in the gastrointestinal system, known as the gut microbiota, is essential to preserving human health and equilibrium. The pathophysiology of several chronic illnesses, including as neurological, cardiovascular, immunological, and metabolic disorders, has been progressively associated with its dysbiosis. This thorough analysis looks at the complex relationships that exist between gut microbiota and host physiology, examining processes including metabolic signaling, immunological regulation, and gut-brain axis communication. We discuss current developments in the study of the microbiome, with an emphasis on the role that the variety and makeup of gut microbes play in the development of chronic diseases. In order to restore microbial balance and lessen the severity of the condition, the study also covers new treatment approaches such as dietary changes, probiotics, prebiotics, and fecal microbiota transplantation. The development of novel, microbiome-based diagnostic and therapeutic strategies is made possible by an understanding of the complex link between the gut microbiota and chronic illnesses, highlighting the vital role that personalized medicine plays in enhancing health outcomes. |
| format | Article |
| id | doaj-art-f6df0a8857a6436f94eecbfb5e7eb42a |
| institution | Matheson Library |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-f6df0a8857a6436f94eecbfb5e7eb42a2025-07-05T11:19:54ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062025-06-0117Suppl 2S1080S108210.4103/jpbs.jpbs_309_25Gut Microbiota and its Impact on Chronic Diseases: A Comprehensive ReviewSahil P. PatelSrushti J. BhoraniyaShruti D. KalolaAtul RukadikarRenju RaviSamreen FarooquiCharushila RukadikarThe intricate community of bacteria that live in the gastrointestinal system, known as the gut microbiota, is essential to preserving human health and equilibrium. The pathophysiology of several chronic illnesses, including as neurological, cardiovascular, immunological, and metabolic disorders, has been progressively associated with its dysbiosis. This thorough analysis looks at the complex relationships that exist between gut microbiota and host physiology, examining processes including metabolic signaling, immunological regulation, and gut-brain axis communication. We discuss current developments in the study of the microbiome, with an emphasis on the role that the variety and makeup of gut microbes play in the development of chronic diseases. In order to restore microbial balance and lessen the severity of the condition, the study also covers new treatment approaches such as dietary changes, probiotics, prebiotics, and fecal microbiota transplantation. The development of novel, microbiome-based diagnostic and therapeutic strategies is made possible by an understanding of the complex link between the gut microbiota and chronic illnesses, highlighting the vital role that personalized medicine plays in enhancing health outcomes.https://journals.lww.com/10.4103/jpbs.jpbs_309_25autoimmune conditionchronic diseasesdietary interventionsdysbiosisfecal microbiota transplantationgastrointestinal tractgut microbiotametabolic disordersmicrobial balance |
| spellingShingle | Sahil P. Patel Srushti J. Bhoraniya Shruti D. Kalola Atul Rukadikar Renju Ravi Samreen Farooqui Charushila Rukadikar Gut Microbiota and its Impact on Chronic Diseases: A Comprehensive Review Journal of Pharmacy and Bioallied Sciences autoimmune condition chronic diseases dietary interventions dysbiosis fecal microbiota transplantation gastrointestinal tract gut microbiota metabolic disorders microbial balance |
| title | Gut Microbiota and its Impact on Chronic Diseases: A Comprehensive Review |
| title_full | Gut Microbiota and its Impact on Chronic Diseases: A Comprehensive Review |
| title_fullStr | Gut Microbiota and its Impact on Chronic Diseases: A Comprehensive Review |
| title_full_unstemmed | Gut Microbiota and its Impact on Chronic Diseases: A Comprehensive Review |
| title_short | Gut Microbiota and its Impact on Chronic Diseases: A Comprehensive Review |
| title_sort | gut microbiota and its impact on chronic diseases a comprehensive review |
| topic | autoimmune condition chronic diseases dietary interventions dysbiosis fecal microbiota transplantation gastrointestinal tract gut microbiota metabolic disorders microbial balance |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_309_25 |
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