Premorbid factors of early post-stroke cognitive impairment
The aim of this study is to identify and substantiate early cognitive dysfunction in patients with brain damage in the acute period of ischemic stroke.Materials and research methods. The study included 140 elderly patients. The main group included 70 patients of Vascular Surgery Center with a diagno...
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| Format: | Article |
| Language: | Russian |
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Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation
2022-10-01
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| Series: | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
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| Online Access: | https://www.bekhterevreview.com/jour/article/view/719 |
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| author | A. А. Grishina A. M. Tynterova Y. E. Skalin |
| author_facet | A. А. Grishina A. M. Tynterova Y. E. Skalin |
| author_sort | A. А. Grishina |
| collection | DOAJ |
| description | The aim of this study is to identify and substantiate early cognitive dysfunction in patients with brain damage in the acute period of ischemic stroke.Materials and research methods. The study included 140 elderly patients. The main group included 70 patients of Vascular Surgery Center with a diagnosis of ischemic stroke in the carotid pool, the control group consisted of 70 outpatients. Cognitive function and psycho-emotional background were assessed using the Montreal Cognitive Function Scale, tests for kinetic, constructive and ideation praxis, the Stroop test, the Boston Naming Test, the apathy rating scale, the Hospital Anxiety and Depression Scale, and the MFI-20 asthenia scale. Assessment of neuroimaging parameters was carried out usingcomputed tomography. Assessment of long-latency acoustic endogenous evoked potential P300 using the «oddball active» paradigm technique was used for neurophysiological examination.Research results. Ischemic stroke was more often detected in the parietal, frontal lobes and basal ganglia. Moderate cognitive impairment was detected in 57.5% of patients with stroke and 27.5% of the control group. Dementia was diagnosed in 30% of patients in the main group and 5% of the control group. In patients with IS indicators characterizing the executive function, praxis, speech, attention, memory, depression, and apathy were statistically significantly lower comparing with the control group. The analysis of neurophysiological data revealed a statistically significant prolongation of the latency of the P300 wave in all leads and a decrease in the amplitude of the P300 peak in leads Cz and C3 in patients of the main group. Conclusion. Within the framework of this study, significant factors in the development of early post-stroke cognitive impairment were established. Dysfunction in attention, executive function, episodic memory, and speech is the result of a combination of causes directly related to cerebrovascular disease and pre-stroke factors. The evoked potential method reflects the degree of cognitive decline and can be used as a method for assessing the effectiveness of cognitive rehabilitation in stroke patients. |
| format | Article |
| id | doaj-art-f6cbaac6dea84cd7a9da989e4f9ec4a6 |
| institution | Matheson Library |
| issn | 2313-7053 2713-055X |
| language | Russian |
| publishDate | 2022-10-01 |
| publisher | Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation |
| record_format | Article |
| series | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
| spelling | doaj-art-f6cbaac6dea84cd7a9da989e4f9ec4a62025-08-03T13:06:38ZrusFederal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian FederationОбозрение психиатрии и медицинской психологии имени В.М. Бехтерева2313-70532713-055X2022-10-01563485610.31363/2313-7053-2022-56-3-48-56453Premorbid factors of early post-stroke cognitive impairmentA. А. Grishina0A. M. Tynterova1Y. E. Skalin2Immanuel Kant Baltic Federal UniversityImmanuel Kant Baltic Federal UniversityImmanuel Kant Baltic Federal UniversityThe aim of this study is to identify and substantiate early cognitive dysfunction in patients with brain damage in the acute period of ischemic stroke.Materials and research methods. The study included 140 elderly patients. The main group included 70 patients of Vascular Surgery Center with a diagnosis of ischemic stroke in the carotid pool, the control group consisted of 70 outpatients. Cognitive function and psycho-emotional background were assessed using the Montreal Cognitive Function Scale, tests for kinetic, constructive and ideation praxis, the Stroop test, the Boston Naming Test, the apathy rating scale, the Hospital Anxiety and Depression Scale, and the MFI-20 asthenia scale. Assessment of neuroimaging parameters was carried out usingcomputed tomography. Assessment of long-latency acoustic endogenous evoked potential P300 using the «oddball active» paradigm technique was used for neurophysiological examination.Research results. Ischemic stroke was more often detected in the parietal, frontal lobes and basal ganglia. Moderate cognitive impairment was detected in 57.5% of patients with stroke and 27.5% of the control group. Dementia was diagnosed in 30% of patients in the main group and 5% of the control group. In patients with IS indicators characterizing the executive function, praxis, speech, attention, memory, depression, and apathy were statistically significantly lower comparing with the control group. The analysis of neurophysiological data revealed a statistically significant prolongation of the latency of the P300 wave in all leads and a decrease in the amplitude of the P300 peak in leads Cz and C3 in patients of the main group. Conclusion. Within the framework of this study, significant factors in the development of early post-stroke cognitive impairment were established. Dysfunction in attention, executive function, episodic memory, and speech is the result of a combination of causes directly related to cerebrovascular disease and pre-stroke factors. The evoked potential method reflects the degree of cognitive decline and can be used as a method for assessing the effectiveness of cognitive rehabilitation in stroke patients.https://www.bekhterevreview.com/jour/article/view/719ischemic strokecognitive functionevoked potentialsold agepremorbid background |
| spellingShingle | A. А. Grishina A. M. Tynterova Y. E. Skalin Premorbid factors of early post-stroke cognitive impairment Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева ischemic stroke cognitive function evoked potentials old age premorbid background |
| title | Premorbid factors of early post-stroke cognitive impairment |
| title_full | Premorbid factors of early post-stroke cognitive impairment |
| title_fullStr | Premorbid factors of early post-stroke cognitive impairment |
| title_full_unstemmed | Premorbid factors of early post-stroke cognitive impairment |
| title_short | Premorbid factors of early post-stroke cognitive impairment |
| title_sort | premorbid factors of early post stroke cognitive impairment |
| topic | ischemic stroke cognitive function evoked potentials old age premorbid background |
| url | https://www.bekhterevreview.com/jour/article/view/719 |
| work_keys_str_mv | AT aagrishina premorbidfactorsofearlypoststrokecognitiveimpairment AT amtynterova premorbidfactorsofearlypoststrokecognitiveimpairment AT yeskalin premorbidfactorsofearlypoststrokecognitiveimpairment |