Valproate-induced disorders of dopamine metabolism and the development of valproate-induced parkinsonism: a new perspective on prevention and diagnosis
The problem of valproate-induced adverse drug reactions, including valproate-induced parkinsonism is of high relevance due to the widespread use of valproates in psychiatric and neurological practice and the complexity of the pathogenesis of dopaminergic neurotransmission disorders. Unfortunately, p...
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| Format: | Article |
| Language: | Russian |
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Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation
2025-06-01
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| Series: | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
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| Online Access: | https://www.bekhterevreview.com/jour/article/view/1133 |
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| author | N. A. Shnayder V. V. Grechkina M. Y. Kissin R. F. Nasyrova |
| author_facet | N. A. Shnayder V. V. Grechkina M. Y. Kissin R. F. Nasyrova |
| author_sort | N. A. Shnayder |
| collection | DOAJ |
| description | The problem of valproate-induced adverse drug reactions, including valproate-induced parkinsonism is of high relevance due to the widespread use of valproates in psychiatric and neurological practice and the complexity of the pathogenesis of dopaminergic neurotransmission disorders. Unfortunately, personalized algorithms for practicing physicians based on the use of modern methods of pharmacogenomics and pharmacometabolomics of valproate-induced parkinsonism have not yet been developed. The most important methods of diagnosis and prognosis of valproate-induced parkinsonism are 1) investigation of neurologic status (assessment of motor and non-motor symptoms of drug-induced parkinsonism); 2) therapeutic drug monitoring of total and free fractions of valproic acid; 3) study of the level of toxic metabolic metabolites of valproic acid in blood and urine; pharmacogenetic testing of non-functional single nucleotide variants of genes encoding key metabolic enzymes and key transport proteins of valproic acid efflux across the blood-brain barrier. |
| format | Article |
| id | doaj-art-f566d3bbcec4493cbec0c5c6f3c0f74e |
| institution | Matheson Library |
| issn | 2313-7053 2713-055X |
| language | Russian |
| publishDate | 2025-06-01 |
| publisher | Federal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian Federation |
| record_format | Article |
| series | Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева |
| spelling | doaj-art-f566d3bbcec4493cbec0c5c6f3c0f74e2025-08-03T13:06:39ZrusFederal State Budget Scientific Institution National Medical Research Center for Psychiatry and Neurology n.a. V.M. Bekhterev Ministry of Health of the Russian FederationОбозрение психиатрии и медицинской психологии имени В.М. Бехтерева2313-70532713-055X2025-06-01592405110.31363/2313-7053-2025-2-951606Valproate-induced disorders of dopamine metabolism and the development of valproate-induced parkinsonism: a new perspective on prevention and diagnosisN. A. Shnayder0V. V. Grechkina1M. Y. Kissin2R. F. Nasyrova3V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology; V.F. Voyno-Yasenetsky Krasnoyarsk State Medical UniversityV.M. Bekhterev National Medical Research Center for Psychiatry and NeurologyPavlov First St. Petersburg State Medical UniversityV.M. Bekhterev National Medical Research Center for Psychiatry and Neurology; Tula State UniversityThe problem of valproate-induced adverse drug reactions, including valproate-induced parkinsonism is of high relevance due to the widespread use of valproates in psychiatric and neurological practice and the complexity of the pathogenesis of dopaminergic neurotransmission disorders. Unfortunately, personalized algorithms for practicing physicians based on the use of modern methods of pharmacogenomics and pharmacometabolomics of valproate-induced parkinsonism have not yet been developed. The most important methods of diagnosis and prognosis of valproate-induced parkinsonism are 1) investigation of neurologic status (assessment of motor and non-motor symptoms of drug-induced parkinsonism); 2) therapeutic drug monitoring of total and free fractions of valproic acid; 3) study of the level of toxic metabolic metabolites of valproic acid in blood and urine; pharmacogenetic testing of non-functional single nucleotide variants of genes encoding key metabolic enzymes and key transport proteins of valproic acid efflux across the blood-brain barrier.https://www.bekhterevreview.com/jour/article/view/1133valproic acidextrapyramidal disordersvalproate-induced parkinsonismpersonalized neurologypersonalized psychiatrypharmacogenetics |
| spellingShingle | N. A. Shnayder V. V. Grechkina M. Y. Kissin R. F. Nasyrova Valproate-induced disorders of dopamine metabolism and the development of valproate-induced parkinsonism: a new perspective on prevention and diagnosis Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева valproic acid extrapyramidal disorders valproate-induced parkinsonism personalized neurology personalized psychiatry pharmacogenetics |
| title | Valproate-induced disorders of dopamine metabolism and the development of valproate-induced parkinsonism: a new perspective on prevention and diagnosis |
| title_full | Valproate-induced disorders of dopamine metabolism and the development of valproate-induced parkinsonism: a new perspective on prevention and diagnosis |
| title_fullStr | Valproate-induced disorders of dopamine metabolism and the development of valproate-induced parkinsonism: a new perspective on prevention and diagnosis |
| title_full_unstemmed | Valproate-induced disorders of dopamine metabolism and the development of valproate-induced parkinsonism: a new perspective on prevention and diagnosis |
| title_short | Valproate-induced disorders of dopamine metabolism and the development of valproate-induced parkinsonism: a new perspective on prevention and diagnosis |
| title_sort | valproate induced disorders of dopamine metabolism and the development of valproate induced parkinsonism a new perspective on prevention and diagnosis |
| topic | valproic acid extrapyramidal disorders valproate-induced parkinsonism personalized neurology personalized psychiatry pharmacogenetics |
| url | https://www.bekhterevreview.com/jour/article/view/1133 |
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