STAT3 mediates CAF-induced osimertinib resistance via regulating protein secretion in non-small cell lung cancer

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STAT3 mediates CAF-induced osimertinib resistance via regulating protein secretion in non-small cell lung cancer

IntroductionEGFR-TKI resistance is an important factor limiting the clinical application of targeted drugs in NSCLC, but the mechanism remains unclear. The tumor microenvironment is the internal environment for cancer cells to survive, and it plays an important role in tumor resistance.MethodsIn vit...

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Bibliographic Details
Main Authors:	Xuchen Fan, Sheng Wu, Honglong Wu, Yingying Huang, Xuhui Tong, Meiling Yu, Zhe Liu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Pharmacology
Subjects:	tumor microenvironment cancer associated fibroblasts osimertinib resistance signal transducer and activator of transcription 3 non-small cell lung cancer
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1546491/full
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