STAT3 mediates CAF-induced osimertinib resistance via regulating protein secretion in non-small cell lung cancer

STAT3 mediates CAF-induced osimertinib resistance via regulating protein secretion in non-small cell lung cancer

IntroductionEGFR-TKI resistance is an important factor limiting the clinical application of targeted drugs in NSCLC, but the mechanism remains unclear. The tumor microenvironment is the internal environment for cancer cells to survive, and it plays an important role in tumor resistance.MethodsIn vit...

Full description

Saved in:
Bibliographic Details
Main Authors: Xuchen Fan, Sheng Wu, Honglong Wu, Yingying Huang, Xuhui Tong, Meiling Yu, Zhe Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
tumor microenvironment
cancer associated fibroblasts
osimertinib resistance
signal transducer and activator of transcription 3
non-small cell lung cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1546491/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items