Integration of co-culture conditions and 3D gelatin methacryloyl hydrogels to improve human-induced pluripotent stem cells-derived cardiomyocytes maturation

Integration of co-culture conditions and 3D gelatin methacryloyl hydrogels to improve human-induced pluripotent stem cells-derived cardiomyocytes maturation

IntroductionHuman-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) represent an excellent alternative to animals for in vitro cardiac studies. However, their immature fetal phenotype represents an important limit to consider. Approaches proposed to overcome this issue are based on be...

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Main Authors: Ilaria Gisone, Monica Boffito, Elisa Persiani, Roberta Pappalardo, Elisa Ceccherini, Andrea Alliaud, Manuela Cabiati, Rossella Laurano, Letizia Guiducci, Chiara Caselli, Rosetta Ragusa, Claudio Cassino, Chiara Ippolito, Silvia Del Ry, Susanna Sartori, Antonella Cecchettini, Salvador Fernández-Arroyo, Gianluca Ciardelli, Federico Vozzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
hiPSCs differentiation
hiPSC-CMs culture
3D model
hydrogels
gelatin methacryloyl
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1576824/full
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https://www.frontiersin.org/articles/10.3389/fbioe.2025.1576824/full

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