Immunologic and Hormonal Effects of Prophylthiouracil Treatment Using Maintenance Dose in Graves’ Disease Patients

Immunologic and Hormonal Effects of Prophylthiouracil Treatment Using Maintenance Dose in Graves’ Disease Patients

Show other versions (1)

Aim: to assess immunologic remission in patients with Graves’ disease following euthyroid condition at the end of treatment with maintenance dose of PTU. Methods: this is an intervention study using one-group pre-post design. Subjects were 25 Graves‘ disease patients visiting Metabolic Endocrinolog...

Full description

Saved in:
Bibliographic Details
Main Authors: Eva Decroli, Asman Manaf, Syafril Syahbuddin
Format: Article
Language:English
Published: Interna Publishing 2014-10-01
Series:Acta Medica Indonesiana
Online Access:https://mail.actamedindones.org/index.php/ijim/article/view/105
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aim: to assess immunologic remission in patients with Graves’ disease following euthyroid condition at the end of treatment with maintenance dose of PTU. Methods: this is an intervention study using one-group pre-post design. Subjects were 25 Graves‘ disease patients visiting Metabolic Endocrinology Clinic at Dr. M.Djamil hospital Padang and met the inclusion criteria. Patients were given PTU treatment for 12 months. Blood samples were taken at the beginning and at the end of treatment to determine immunological remission reflected by differences in IL-4serum levels. Results: after maintenance therapy, we found significant decrease of T3 levels (2.29±0.57 nmol/L vs. 1.87±0.34 nmol/L, p<0.05), significant decrease of T4 levels (118.15±25.99 nmol/L vs. 94.15±23.76 nmol/L, p<0.05), significant increase of TSH levels (0.379±0.548 vs. 0.859±0.990, p<0.05) and significant decreased levels of IL-4 (12.23±5.74 vs. 3.84±0.42, p<0.05). The IL-4 level, however, did not decrease to the normal levels. Conclusion: PTU administration in maintenance dose can significantly reduce thyroid hormonal parameter levels down to euthyroid condition, but cannot reduce immunological parameter (IL4) to normal limit. Key words: hormonal, immunologic, interleukin-4, Graves’ disease.
ISSN:0125-9326
2338-2732

Similar Items