TREX1 activators: A novel therapeutic strategy for rheumatoid arthritis management via cfDNA clearance

TREX1 activators: A novel therapeutic strategy for rheumatoid arthritis management via cfDNA clearance

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by systemic inflammation and progressive joint destruction. Although current treatments, including conventional disease-modifying antirheumatic drugs (DMARDs) and biologics, offer therapeutic benefits, they are often associated...

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Bibliographic Details
Main Authors: Yuping Wang, Weidan Luo, Wanyu Wu, Chang Chen, Bo Qin, Xiongfei Xu, Yulin Xu, Jianghuiyi Zeng, Linna Wang, Jiujie Yang, Jerome P.L. Ng, Wuyan Zheng, Xiaoyun Yun, Jie Zhou, Baixiong Huang, Betty Yuen-Kwan Law, Vincent Kam-Wai Wong
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Pharmacological Research
Subjects:
Rheumatoid arthritis
Cell-free DNA (cfDNA) clearance
TREX1
Pterostilbene (PTE)
Bilobalide (BB)
Natural compounds
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825002427
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