VCPIP1 potentiates innate immune responses by non-catalytically reducing the ubiquitination of IRAK1/2

VCPIP1 potentiates innate immune responses by non-catalytically reducing the ubiquitination of IRAK1/2

Summary: The host innate immune system is efficiently activated after recognizing microbial components, such as lipopolysaccharide (LPS), by Toll-like receptors (TLRs). However, the molecular basis for the regulation of TLR-mediated signaling remains poorly understood. Here, we report that valosin c...

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Bibliographic Details
Main Authors: Liyan Lou, Jiangyun Shen, Jianzhao Zhang, Fuqi Mei, Deyu Deng, Deqi Wang, Yanqi Xu, Kangmin Chen, Baoli Cheng, Jinghua Liu, Xu Wang
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Cell Reports
Subjects:
CP: Immunology
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725007028
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