The Role of Intestinal Microbiota and Dietary Fibre in the Regulation of Blood Pressure Through the Interaction with Sodium: A Narrative Review
Sodium consumption is a well-established risk factor for the development of hypertension. Nevertheless, current recommendations for reducing dietary sodium intake are challenging to implement. Consequently, alternative approaches that would reduce the harmful health effects of excessive sodium consu...
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MDPI AG
2025-05-01
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| author | Agnieszka Rudzka Dorota Zielińska Katarzyna Neffe-Skocińska Barbara Sionek Aleksandra Szydłowska Karolina Górnik-Horn Danuta Kołożyn-Krajewska |
| author_facet | Agnieszka Rudzka Dorota Zielińska Katarzyna Neffe-Skocińska Barbara Sionek Aleksandra Szydłowska Karolina Górnik-Horn Danuta Kołożyn-Krajewska |
| author_sort | Agnieszka Rudzka |
| collection | DOAJ |
| description | Sodium consumption is a well-established risk factor for the development of hypertension. Nevertheless, current recommendations for reducing dietary sodium intake are challenging to implement. Consequently, alternative approaches that would reduce the harmful health effects of excessive sodium consumption on blood pressure are highly desirable. The scientific evidence suggests that dietary fibre intake and human intestinal microbiota may affect blood pressure regulation, potentially through interactions with sodium. This narrative review aims to explore the complex interactions between microbiota, fibre, and the fate of sodium in the human body, as well as the implications of these interactions in the prevention and treatment of hypertension. The relevant literature, published up to March 2025, was searched across databases including Google, Google Scholar, PubMed, and Web of Science. A total of 160 most relevant references were included. Gathered evidence suggests that while dietary fibre may reduce sodium uptake into the bloodstream by binding sodium ions and bile salts, microbiota may also contribute to lowering sodium bioavailability thanks to multiple metabolites with anti-inflammatory and intestinal sodium transporter-modulating properties. Despite these promising findings, further work is needed to allow the translation of these insights into effective therapeutic approaches, particularly for salt-sensitive, hypertensive individuals. |
| format | Article |
| id | doaj-art-f3c68d5456bb4ba29b7a8bc3ec61bd23 |
| institution | Matheson Library |
| issn | 2076-2607 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
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| series | Microorganisms |
| spelling | doaj-art-f3c68d5456bb4ba29b7a8bc3ec61bd232025-06-25T14:12:17ZengMDPI AGMicroorganisms2076-26072025-05-01136126910.3390/microorganisms13061269The Role of Intestinal Microbiota and Dietary Fibre in the Regulation of Blood Pressure Through the Interaction with Sodium: A Narrative ReviewAgnieszka Rudzka0Dorota Zielińska1Katarzyna Neffe-Skocińska2Barbara Sionek3Aleksandra Szydłowska4Karolina Górnik-Horn5Danuta Kołożyn-Krajewska6Department of Dietetics and Food Studies, Faculty of Science and Technology, Jan Dlugosz University in Czestochowa, Al. Armii Krajowej 13/15, 42-200 Czestochowa, PolandInstitute of Human Nutrition Sciences, Department of Gastronomic Technology and Food Hygiene, Faculty of Human Nutrition, Warsaw University of Life Sciences, Nowoursynowska 159 C, 02-776 Warsaw, PolandInstitute of Human Nutrition Sciences, Department of Gastronomic Technology and Food Hygiene, Faculty of Human Nutrition, Warsaw University of Life Sciences, Nowoursynowska 159 C, 02-776 Warsaw, PolandInstitute of Human Nutrition Sciences, Department of Gastronomic Technology and Food Hygiene, Faculty of Human Nutrition, Warsaw University of Life Sciences, Nowoursynowska 159 C, 02-776 Warsaw, PolandInstitute of Human Nutrition Sciences, Department of Gastronomic Technology and Food Hygiene, Faculty of Human Nutrition, Warsaw University of Life Sciences, Nowoursynowska 159 C, 02-776 Warsaw, PolandDepartment of Dietetics and Food Studies, Faculty of Science and Technology, Jan Dlugosz University in Czestochowa, Al. Armii Krajowej 13/15, 42-200 Czestochowa, PolandDepartment of Dietetics and Food Studies, Faculty of Science and Technology, Jan Dlugosz University in Czestochowa, Al. Armii Krajowej 13/15, 42-200 Czestochowa, PolandSodium consumption is a well-established risk factor for the development of hypertension. Nevertheless, current recommendations for reducing dietary sodium intake are challenging to implement. Consequently, alternative approaches that would reduce the harmful health effects of excessive sodium consumption on blood pressure are highly desirable. The scientific evidence suggests that dietary fibre intake and human intestinal microbiota may affect blood pressure regulation, potentially through interactions with sodium. This narrative review aims to explore the complex interactions between microbiota, fibre, and the fate of sodium in the human body, as well as the implications of these interactions in the prevention and treatment of hypertension. The relevant literature, published up to March 2025, was searched across databases including Google, Google Scholar, PubMed, and Web of Science. A total of 160 most relevant references were included. Gathered evidence suggests that while dietary fibre may reduce sodium uptake into the bloodstream by binding sodium ions and bile salts, microbiota may also contribute to lowering sodium bioavailability thanks to multiple metabolites with anti-inflammatory and intestinal sodium transporter-modulating properties. Despite these promising findings, further work is needed to allow the translation of these insights into effective therapeutic approaches, particularly for salt-sensitive, hypertensive individuals.https://www.mdpi.com/2076-2607/13/6/1269hypertensionsodiumfibregut microbiotasodium bioavailability |
| spellingShingle | Agnieszka Rudzka Dorota Zielińska Katarzyna Neffe-Skocińska Barbara Sionek Aleksandra Szydłowska Karolina Górnik-Horn Danuta Kołożyn-Krajewska The Role of Intestinal Microbiota and Dietary Fibre in the Regulation of Blood Pressure Through the Interaction with Sodium: A Narrative Review Microorganisms hypertension sodium fibre gut microbiota sodium bioavailability |
| title | The Role of Intestinal Microbiota and Dietary Fibre in the Regulation of Blood Pressure Through the Interaction with Sodium: A Narrative Review |
| title_full | The Role of Intestinal Microbiota and Dietary Fibre in the Regulation of Blood Pressure Through the Interaction with Sodium: A Narrative Review |
| title_fullStr | The Role of Intestinal Microbiota and Dietary Fibre in the Regulation of Blood Pressure Through the Interaction with Sodium: A Narrative Review |
| title_full_unstemmed | The Role of Intestinal Microbiota and Dietary Fibre in the Regulation of Blood Pressure Through the Interaction with Sodium: A Narrative Review |
| title_short | The Role of Intestinal Microbiota and Dietary Fibre in the Regulation of Blood Pressure Through the Interaction with Sodium: A Narrative Review |
| title_sort | role of intestinal microbiota and dietary fibre in the regulation of blood pressure through the interaction with sodium a narrative review |
| topic | hypertension sodium fibre gut microbiota sodium bioavailability |
| url | https://www.mdpi.com/2076-2607/13/6/1269 |
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