Evaluation of the antinociceptive potential of sodium valproate in mice
Recent research in the field of algesiology demonstrated the existence of several types of pain, with complex mediation cascades. This fact prompted the use of compounds from other drug families than classical analgesics for the treatment of pain. The purpose of this paper is to demonstrate the anti...
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| Format: | Article |
| Language: | English |
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Asociaţia Naţională a Fabricanţilor de Produse de Uz Veterinar
2014-06-01
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| Series: | Medicamentul Veterinar |
| Online Access: | http://www.veterinarypharmacon.com/docs/1347-2014-VD-8-1-ART.11.EN.pdf |
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| _version_ | 1839595223419715584 |
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| author | Lidia Cristina Chitac Sorin Beschea Monica Neamtu Delia Bulea Veronica Bild |
| author_facet | Lidia Cristina Chitac Sorin Beschea Monica Neamtu Delia Bulea Veronica Bild |
| author_sort | Lidia Cristina Chitac |
| collection | DOAJ |
| description | Recent research in the field of algesiology demonstrated the existence of several types of pain, with complex mediation cascades. This fact prompted the use of compounds from other drug families than classical analgesics for the treatment of pain. The purpose of this paper is to demonstrate the antinociceptive action of sodium valproate in mice. This investigation relies on three nociception models that use chemical, thermal, mechanical (pressure) stimuli, and a model of acute inflammation induced by carrageenan. The investigations were made using male white Swiss mice, weighing 20-30 grams.
Valproate administration has been made orally, using geometric progression dose sequences. According to the statistical analysis, we obtained values of ED50 for sodium valproate for each nociception model as follows: ED50 = 21.773 ± 6.786 mg/kg for the nociception model with Zymosan A, ED50 = 11.807 ± 4.035 mg/kg, for the hot plate test, ED50 = 19.247 ± 2.207 mg/kg for the Randall-Sellitto test. The action of the valproate is explained by the inhibition of pro-inflammatory cytokines like TNF-D IL1E, IL6 and prostaglandin mediators like PGE2. The experiments were made according to the European and Romanian legislation that concerns working with lab animals. |
| format | Article |
| id | doaj-art-f39d84fcda544af3a58ae6521c7de726 |
| institution | Matheson Library |
| issn | 1843-9527 2069-2463 |
| language | English |
| publishDate | 2014-06-01 |
| publisher | Asociaţia Naţională a Fabricanţilor de Produse de Uz Veterinar |
| record_format | Article |
| series | Medicamentul Veterinar |
| spelling | doaj-art-f39d84fcda544af3a58ae6521c7de7262025-08-02T23:23:08ZengAsociaţia Naţională a Fabricanţilor de Produse de Uz VeterinarMedicamentul Veterinar1843-95272069-24632014-06-01819297Evaluation of the antinociceptive potential of sodium valproate in miceLidia Cristina Chitac0Sorin Beschea1Monica Neamtu 2Delia Bulea3Veronica Bild 4Department of Pharmacodynamics and Clinical Pharmacy, University of Medicine and Pharmacy, „Grigore. T. Popa” Iasi Department of Toxicology, Faculty of Veterinary Medicine, USAMV IasiDepartment of Pharmacodynamics and Clinical Pharmacy, University of Medicine and Pharmacy, „Grigore. T. Popa” Iasi Department of Pharmacodynamics and Clinical Pharmacy, University of Medicine and Pharmacy, „Grigore. T. Popa” Iasi Department of Pharmacodynamics and Clinical Pharmacy, University of Medicine and Pharmacy, „Grigore. T. Popa” Iasi Recent research in the field of algesiology demonstrated the existence of several types of pain, with complex mediation cascades. This fact prompted the use of compounds from other drug families than classical analgesics for the treatment of pain. The purpose of this paper is to demonstrate the antinociceptive action of sodium valproate in mice. This investigation relies on three nociception models that use chemical, thermal, mechanical (pressure) stimuli, and a model of acute inflammation induced by carrageenan. The investigations were made using male white Swiss mice, weighing 20-30 grams. Valproate administration has been made orally, using geometric progression dose sequences. According to the statistical analysis, we obtained values of ED50 for sodium valproate for each nociception model as follows: ED50 = 21.773 ± 6.786 mg/kg for the nociception model with Zymosan A, ED50 = 11.807 ± 4.035 mg/kg, for the hot plate test, ED50 = 19.247 ± 2.207 mg/kg for the Randall-Sellitto test. The action of the valproate is explained by the inhibition of pro-inflammatory cytokines like TNF-D IL1E, IL6 and prostaglandin mediators like PGE2. The experiments were made according to the European and Romanian legislation that concerns working with lab animals.http://www.veterinarypharmacon.com/docs/1347-2014-VD-8-1-ART.11.EN.pdf |
| spellingShingle | Lidia Cristina Chitac Sorin Beschea Monica Neamtu Delia Bulea Veronica Bild Evaluation of the antinociceptive potential of sodium valproate in mice Medicamentul Veterinar |
| title | Evaluation of the antinociceptive potential of sodium valproate in mice |
| title_full | Evaluation of the antinociceptive potential of sodium valproate in mice |
| title_fullStr | Evaluation of the antinociceptive potential of sodium valproate in mice |
| title_full_unstemmed | Evaluation of the antinociceptive potential of sodium valproate in mice |
| title_short | Evaluation of the antinociceptive potential of sodium valproate in mice |
| title_sort | evaluation of the antinociceptive potential of sodium valproate in mice |
| url | http://www.veterinarypharmacon.com/docs/1347-2014-VD-8-1-ART.11.EN.pdf |
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