Cagrilintide lowers bodyweight through brain amylin receptors 1 and 3Research in context

Cagrilintide lowers bodyweight through brain amylin receptors 1 and 3Research in context

Summary: Background: Amylin (AmyR) and calcitonin (CTR) receptor co-agonists are currently in Phase II/III clinical trials for obesity treatment. Amylin binds to a heterodimeric receptor composed of CTR and the receptor activity modifying proteins 1, 2 or 3 (RAMP1-3). Methods: We investigated the r...

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Bibliographic Details
Main Authors: Alexandra Oliveira Carvas, Andrea Leuthardt, Patricia Kulka, Greta Lommi, Shad Hassan, Bernd Coester, Sofia Lundh, Tune Pers, Anna Secher, Kirsten Raun, Thomas A. Lutz, Christelle Le Foll
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:EBioMedicine
Subjects:
Amylin
Hindbrain
Mouse
Weight
Food intake
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425002804
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