Hydroxyethyl starch-curcumin nanoparticles ameliorate DSS-induced ulcerative colitis in mice via synergistic TLR4/NF-κB suppression, Nrf2 activation, intestinal barrier restoration, and gut microbiota modulation

Hydroxyethyl starch-curcumin nanoparticles ameliorate DSS-induced ulcerative colitis in mice via synergistic TLR4/NF-κB suppression, Nrf2 activation, intestinal barrier restoration, and gut microbiota modulation

Here, we systematically evaluated the therapeutic efficacy and mechanisms of action of in-house synthesized hydroxyethyl starch-curcumin nanoparticles (HES-CUR NPs) in ulcerative colitis (UC). Using a dextran sodium sulfate (DSS)-induced UC mouse model, we analyzed the effect of HES-CUR NPs on colon...

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Bibliographic Details
Main Authors: Sheng Li, Shiyi Lu, Jiahui Xiong, Liang Chen, Yanting Lin, Xiaohui Chen, Xinyi Wang, Lijing Lin, Xiaoliang Cai, Xiaoyu Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
curcumin
ulcerative colitis
gut microbiota
TLR4/NF-κB
Nrf2
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1610711/full
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