Neuromodulation of the Cardiac Autonomic Nervous System for Arrhythmia Treatment
This review explores current and emerging neuromodulation techniques targeting the cardiac autonomic nervous system for the treatment and prevention of atrial and ventricular arrhythmias. Arrhythmias remain a significant cause of morbidity and mortality, with the autonomic nervous system playing a c...
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MDPI AG
2025-07-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/13/7/1776 |
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| author | Benjamin Wong Yuki Kuwabara Siamak Salavatian |
| author_facet | Benjamin Wong Yuki Kuwabara Siamak Salavatian |
| author_sort | Benjamin Wong |
| collection | DOAJ |
| description | This review explores current and emerging neuromodulation techniques targeting the cardiac autonomic nervous system for the treatment and prevention of atrial and ventricular arrhythmias. Arrhythmias remain a significant cause of morbidity and mortality, with the autonomic nervous system playing a crucial role in arrhythmogenesis. Interventions span surgical, pharmacological, and bioelectronic methods. We discuss the range of neuromodulation methods targeting the stellate ganglion, the spinal region, the parasympathetic system, and other promising methods. These include stellate ganglion block, stellate ganglion ablation, cardiac sympathetic denervation, subcutaneous electrical stimulation, thoracic epidural anesthesia, spinal cord stimulation, dorsal root ganglion stimulation, vagus nerve stimulation, baroreflex activation therapy, carotid body ablation, renal denervation, ganglionated plexi ablation, acupuncture, and transcutaneous magnetic stimulation. Both preclinical and clinical studies are presented as evidence for arrhythmia management. |
| format | Article |
| id | doaj-art-f32f91f3bb0640e2be35b5e82f1e4293 |
| institution | Matheson Library |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-f32f91f3bb0640e2be35b5e82f1e42932025-07-25T13:16:05ZengMDPI AGBiomedicines2227-90592025-07-01137177610.3390/biomedicines13071776Neuromodulation of the Cardiac Autonomic Nervous System for Arrhythmia TreatmentBenjamin Wong0Yuki Kuwabara1Siamak Salavatian2Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USADepartment of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USADepartment of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USAThis review explores current and emerging neuromodulation techniques targeting the cardiac autonomic nervous system for the treatment and prevention of atrial and ventricular arrhythmias. Arrhythmias remain a significant cause of morbidity and mortality, with the autonomic nervous system playing a crucial role in arrhythmogenesis. Interventions span surgical, pharmacological, and bioelectronic methods. We discuss the range of neuromodulation methods targeting the stellate ganglion, the spinal region, the parasympathetic system, and other promising methods. These include stellate ganglion block, stellate ganglion ablation, cardiac sympathetic denervation, subcutaneous electrical stimulation, thoracic epidural anesthesia, spinal cord stimulation, dorsal root ganglion stimulation, vagus nerve stimulation, baroreflex activation therapy, carotid body ablation, renal denervation, ganglionated plexi ablation, acupuncture, and transcutaneous magnetic stimulation. Both preclinical and clinical studies are presented as evidence for arrhythmia management.https://www.mdpi.com/2227-9059/13/7/1776neuromodulationatrial arrhythmiasventricular arrhythmias |
| spellingShingle | Benjamin Wong Yuki Kuwabara Siamak Salavatian Neuromodulation of the Cardiac Autonomic Nervous System for Arrhythmia Treatment Biomedicines neuromodulation atrial arrhythmias ventricular arrhythmias |
| title | Neuromodulation of the Cardiac Autonomic Nervous System for Arrhythmia Treatment |
| title_full | Neuromodulation of the Cardiac Autonomic Nervous System for Arrhythmia Treatment |
| title_fullStr | Neuromodulation of the Cardiac Autonomic Nervous System for Arrhythmia Treatment |
| title_full_unstemmed | Neuromodulation of the Cardiac Autonomic Nervous System for Arrhythmia Treatment |
| title_short | Neuromodulation of the Cardiac Autonomic Nervous System for Arrhythmia Treatment |
| title_sort | neuromodulation of the cardiac autonomic nervous system for arrhythmia treatment |
| topic | neuromodulation atrial arrhythmias ventricular arrhythmias |
| url | https://www.mdpi.com/2227-9059/13/7/1776 |
| work_keys_str_mv | AT benjaminwong neuromodulationofthecardiacautonomicnervoussystemforarrhythmiatreatment AT yukikuwabara neuromodulationofthecardiacautonomicnervoussystemforarrhythmiatreatment AT siamaksalavatian neuromodulationofthecardiacautonomicnervoussystemforarrhythmiatreatment |