Ablation of macrophage transcriptional factor FoxO1 protects against ischemia–reperfusion injury-induced acute kidney injury

Ablation of macrophage transcriptional factor FoxO1 protects against ischemia–reperfusion injury-induced acute kidney injury

Acute kidney injury (AKI) has high morbidity and mortality, but effective clinical drugs and management are lacking. Previous studies have suggested that macrophages play a crucial role in the inflammatory response to AKI and may serve as potential therapeutic targets. Emerging evidence has highligh...

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Main Authors: Yao He, Xue Yang, Chenyu Zhang, Min Deng, Bin Tu, Qian Liu, Jiaying Cai, Ying Zhang, Li Su, Zhiwen Yang, Hongfeng Xu, Zhongyuan Zheng, Qun Ma, Xi Wang, Xuejun Li, Linlin Li, Long Zhang, Yongzhuo Huang, Lu Tie
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Acta Pharmaceutica Sinica B
Subjects:
AKI
I/R injury
FoxO1
Macrophage
Chemotaxis
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525002412
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