Sequence simplification of antigen coding IVT mRNA allows accelerated synthetic DNA template generation and epitope immunogenicity validation
The recent surge in therapeutic mRNA for vaccination has provided a blueprint for the design of the mRNA molecule, as several complex structural elements indicated as 5′ and 3′ untranslated regions (UTRs) and poly-A tail have been identified as necessary for in vitro transcribed mRNA stability and r...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-09-01
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| Series: | Molecular Therapy: Nucleic Acids |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2162253125001453 |
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