MECOPE: Multifocal excitation compressive-sensing photoacoustic endomicroscopy through a multimode fibre
Photoacoustic endoscopy has gained intensive research interest in recent years, particularly for guiding minimally invasive procedures in several clinical disciplines including oncology, cardiology and fetal medicine. Multimode fibres hold the potential to revolutionise medical endoscopy with ultrat...
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| Language: | English |
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Elsevier
2025-08-01
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| Series: | Photoacoustics |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213597925000564 |
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| author | Tianrui Zhao Edward Zhang Paul C. Beard Wenfeng Xia |
| author_facet | Tianrui Zhao Edward Zhang Paul C. Beard Wenfeng Xia |
| author_sort | Tianrui Zhao |
| collection | DOAJ |
| description | Photoacoustic endoscopy has gained intensive research interest in recent years, particularly for guiding minimally invasive procedures in several clinical disciplines including oncology, cardiology and fetal medicine. Multimode fibres hold the potential to revolutionise medical endoscopy with ultrathin size and micrometre-level resolution. Compared to conventional endomicroscopes based on multi-core fibre bundles, multimode fibres-based endoscopes offer significantly higher spatial resolution, smaller diameters, and lower costs. However, current implementations of multimode fibre imaging, whether using raster-scan or speckle compressive sensing imaging, are hindered by limitations in frame rate or signal-to-noise ratio. In this work, we developed a multifocal excitation compressive-sensing photoacoustic endomicroscopy system that combines wavefront shaping-based light focusing with compressive sensing to achieve high imaging speed without compromising image quality. The method was validated through numerical simulations and experiments with carbon fibre phantoms and red blood cells ex vivo. Our results demonstrated comparable image quality to raster-scan-based imaging, while improving the frame rate by a factor of 5, reaching 11.5 frames per second. With further enhancements in focusing performance and the use of a higher repetition rate laser, this method shows promise for achieving real-time, high-resolution endomicroscopy through ultrathin probes, making it a valuable tool for guiding minimally invasive procedures. |
| format | Article |
| id | doaj-art-f26aad89ac0340dba6074d09f5ebaec6 |
| institution | Matheson Library |
| issn | 2213-5979 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photoacoustics |
| spelling | doaj-art-f26aad89ac0340dba6074d09f5ebaec62025-06-27T05:50:22ZengElsevierPhotoacoustics2213-59792025-08-0144100733MECOPE: Multifocal excitation compressive-sensing photoacoustic endomicroscopy through a multimode fibreTianrui Zhao0Edward Zhang1Paul C. Beard2Wenfeng Xia3School of Biomedical Engineering and Imaging Sciences, King’s College London, 4th Floor, Lambeth Wing St Thomas’ Hospital, London SE1 7EH, United KingdomDepartment of Medical Physics and Biomedical Engineering, University College London, Gower Street, London WC1E 6BT, United Kingdom; Wellcome/EPSRC Centre for Interventional and Surgical Sciences, University College London, Charles Bell House, 67-73 Riding House Street, London W1W 7EJ, United KingdomDepartment of Medical Physics and Biomedical Engineering, University College London, Gower Street, London WC1E 6BT, United Kingdom; Wellcome/EPSRC Centre for Interventional and Surgical Sciences, University College London, Charles Bell House, 67-73 Riding House Street, London W1W 7EJ, United KingdomSchool of Biomedical Engineering and Imaging Sciences, King’s College London, 4th Floor, Lambeth Wing St Thomas’ Hospital, London SE1 7EH, United Kingdom; Corresponding author.Photoacoustic endoscopy has gained intensive research interest in recent years, particularly for guiding minimally invasive procedures in several clinical disciplines including oncology, cardiology and fetal medicine. Multimode fibres hold the potential to revolutionise medical endoscopy with ultrathin size and micrometre-level resolution. Compared to conventional endomicroscopes based on multi-core fibre bundles, multimode fibres-based endoscopes offer significantly higher spatial resolution, smaller diameters, and lower costs. However, current implementations of multimode fibre imaging, whether using raster-scan or speckle compressive sensing imaging, are hindered by limitations in frame rate or signal-to-noise ratio. In this work, we developed a multifocal excitation compressive-sensing photoacoustic endomicroscopy system that combines wavefront shaping-based light focusing with compressive sensing to achieve high imaging speed without compromising image quality. The method was validated through numerical simulations and experiments with carbon fibre phantoms and red blood cells ex vivo. Our results demonstrated comparable image quality to raster-scan-based imaging, while improving the frame rate by a factor of 5, reaching 11.5 frames per second. With further enhancements in focusing performance and the use of a higher repetition rate laser, this method shows promise for achieving real-time, high-resolution endomicroscopy through ultrathin probes, making it a valuable tool for guiding minimally invasive procedures.http://www.sciencedirect.com/science/article/pii/S2213597925000564Photoacoustic imagingEndoscopyMultimode fibreCompressive sensingWavefront shaping |
| spellingShingle | Tianrui Zhao Edward Zhang Paul C. Beard Wenfeng Xia MECOPE: Multifocal excitation compressive-sensing photoacoustic endomicroscopy through a multimode fibre Photoacoustics Photoacoustic imaging Endoscopy Multimode fibre Compressive sensing Wavefront shaping |
| title | MECOPE: Multifocal excitation compressive-sensing photoacoustic endomicroscopy through a multimode fibre |
| title_full | MECOPE: Multifocal excitation compressive-sensing photoacoustic endomicroscopy through a multimode fibre |
| title_fullStr | MECOPE: Multifocal excitation compressive-sensing photoacoustic endomicroscopy through a multimode fibre |
| title_full_unstemmed | MECOPE: Multifocal excitation compressive-sensing photoacoustic endomicroscopy through a multimode fibre |
| title_short | MECOPE: Multifocal excitation compressive-sensing photoacoustic endomicroscopy through a multimode fibre |
| title_sort | mecope multifocal excitation compressive sensing photoacoustic endomicroscopy through a multimode fibre |
| topic | Photoacoustic imaging Endoscopy Multimode fibre Compressive sensing Wavefront shaping |
| url | http://www.sciencedirect.com/science/article/pii/S2213597925000564 |
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