The importance of antibacterial therapy of whooping cough in children at the outpatient stage of treatment
Background. Whooping cough, a childhood infectious disease that can cause serious and potentially fatal complications, especially in very young children. The main challenge now is early diagnosis of the disease, which will ensure proper treatment and prevent transmission of infection to others.Objec...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Open Systems Publication
2025-06-01
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| Series: | Лечащий Врач |
| Subjects: | |
| Online Access: | https://journal.lvrach.ru/jour/article/view/1428 |
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| Summary: | Background. Whooping cough, a childhood infectious disease that can cause serious and potentially fatal complications, especially in very young children. The main challenge now is early diagnosis of the disease, which will ensure proper treatment and prevent transmission of infection to others.Objective. The purpose of the study was to evaluate the clinical and laboratory manifestations of whooping cough in children of different age groups, taking into account the outpatient prescription of antibacterial drugs.Materials and methods. Clinical cases of whooping cough in patients treated in a children's infectious diseases hospital (n = 114) were analyzed. Inclusion criteria: age from 0 to 17 years, characteristic clinical manifestations of whooping cough, a sample of patients treated on an outpatient basis during the first week of the disease. The average age of the patients was 3.79 ± 4.9 years. Taking into account the age criterion, the patients were divided into 3 groups. Licensed software version Statistica 13 was used. Discriminant analysis was carried out.Results. Before hospitalization in the infectious diseases hospital, the duration of cough in children was 15.4 ± 10.3 days. 63.2% sought outpatient medical care. PCR diagnostics was carried out by the local pediatric service in half of the cases. Treatment with antibacterial drugs was prescribed to 39.5% of patients. In the hospital, patients up to a year had a more severe course, with frequent complications. At the age of up to 3 years, a severe course was observed in 20.0% of patients, and in the group of patients aged 3 years and older – in 5.7% of children. A comparison of changes in the general blood test in children is provided. The results of laboratory examination of patients are described: bacteriological method, PCR diagnostics and results of enzyme immunoassay. The dependence of antibody registration on the duration of the disease in children with whooping cough has been clearly confirmed. The influence of early administration of antibacterial therapy on clinical manifestations and the development of complications in children with whooping cough was revealed.However, the laboratory diagnosis of whooping cough was not affected by outpatient treatment.Conclusion. Early diagnosis and treatment of whooping cough with antibacterial drugs before the paroxysmal stage of the disease can help mitigate the effects and reduce the spread of this highly contagious disease. |
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| ISSN: | 1560-5175 2687-1181 |