JAK inhibitor withdrawal causes a transient pro-inflammatory cascade: A potential mechanism for major adverse cardiac events.

JAK inhibitor withdrawal causes a transient pro-inflammatory cascade: A potential mechanism for major adverse cardiac events.

<h4>Objective</h4>Our objective was to define the effect of JAK inhibitor (JAKinib) withdrawal on JAK/STAT biochemical response in the context of systemic rheumatic diseases.<h4>Methods</h4>We tested Type I (bind kinase active conformation) and Type II (bind kinase inactive c...

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Bibliographic Details
Main Authors: Ilya Gurevic, Loic Meudec, Xavier Mariette, Gaetane Nocturne, Sara S McCoy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0311706
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