Decade-long delayed diagnosis of hypophosphatasia until next generation tooth loss: case reports on dental rehabilitation, diagnostic challenges and clinical implications

Decade-long delayed diagnosis of hypophosphatasia until next generation tooth loss: case reports on dental rehabilitation, diagnostic challenges and clinical implications

Hypophosphatasia (HPP) is a rare metabolic bone disorder caused by functional mutations in the gene Alkaline Phosphatase, Liver/Bone/Kidney (ALPL), resulting in impaired mineralization of bones and teeth. We report a female patient who experienced adolescent teeth loss and underwent dental rehabilit...

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Bibliographic Details
Main Authors: Yating Cao, Feng Zhang, Xingxing Huang, Ai Jiang, Shaoyun Jiang, Min Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Oral Health
Subjects:
delayed diagnosis
hypophosphatasia
tooth loss
dental rehabilitation
case report
Online Access:https://www.frontiersin.org/articles/10.3389/froh.2025.1585188/full
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