Diagnostic Utility of Endocan and Interleukins for Late-Onset Neonatal Sepsis
The aim of this study was to determine the potential of early inflammatory markers to diagnose late-onset neonatal sepsis – interleukin 6 (IL-6), interleukin 8 (IL-8) and endocan (ESM-1), and to compare them with routinely used markers like C-reactive protein (CRP) and procalcitonin (PCT). A prospec...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Medical University - Pleven
2023-12-01
|
| Series: | Journal of Biomedical & Clinical Research |
| Subjects: | |
| Online Access: | https://jbcr.arphahub.com/article/34682/download/pdf/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839616958370152448 |
|---|---|
| author | Preslava Gatseva Alexander Blazhev Zarko Yordanov Victoria Atanasova |
| author_facet | Preslava Gatseva Alexander Blazhev Zarko Yordanov Victoria Atanasova |
| author_sort | Preslava Gatseva |
| collection | DOAJ |
| description | The aim of this study was to determine the potential of early inflammatory markers to diagnose late-onset neonatal sepsis – interleukin 6 (IL-6), interleukin 8 (IL-8) and endocan (ESM-1), and to compare them with routinely used markers like C-reactive protein (CRP) and procalcitonin (PCT). A prospective (January, 2022 – January, 2023) clinical-epidemiological study was conducted in a third level NICU in Pleven, Bulgaria. Patients with suspected nosocomial infection and healthy controls were tested. A sandwich ELISA method was used to measure the serum concentrations. Sixty newborns with an average gestational age of 29.75±3.61 gestational weeks were included, of which 35% were symptomatic and infected, 33.3% were symptomatic but uninfected, and 31.7% were asymptomatic controls. The mean values of PCT and IL-6 differ significantly in the three groups. For ESM-1, IL-8 and CRP, the difference was statistically insignificant. The best sensitivity (78%) and negative predictive value (84%) was found for IL-6. The introduction into routine practice of indicators such as PCT and IL-6 may provide an opportunity to promptly optimize the diagnostic and therapeutic approach to LOS. |
| format | Article |
| id | doaj-art-f1dfac5edb9b48e2ab2a7c24e1cf57f4 |
| institution | Matheson Library |
| issn | 1313-9053 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Medical University - Pleven |
| record_format | Article |
| series | Journal of Biomedical & Clinical Research |
| spelling | doaj-art-f1dfac5edb9b48e2ab2a7c24e1cf57f42025-07-25T07:34:06ZengMedical University - PlevenJournal of Biomedical & Clinical Research1313-90532023-12-0116212413010.2478/jbcr-2023-001634682Diagnostic Utility of Endocan and Interleukins for Late-Onset Neonatal SepsisPreslava GatsevaAlexander BlazhevZarko YordanovVictoria AtanasovaThe aim of this study was to determine the potential of early inflammatory markers to diagnose late-onset neonatal sepsis – interleukin 6 (IL-6), interleukin 8 (IL-8) and endocan (ESM-1), and to compare them with routinely used markers like C-reactive protein (CRP) and procalcitonin (PCT). A prospective (January, 2022 – January, 2023) clinical-epidemiological study was conducted in a third level NICU in Pleven, Bulgaria. Patients with suspected nosocomial infection and healthy controls were tested. A sandwich ELISA method was used to measure the serum concentrations. Sixty newborns with an average gestational age of 29.75±3.61 gestational weeks were included, of which 35% were symptomatic and infected, 33.3% were symptomatic but uninfected, and 31.7% were asymptomatic controls. The mean values of PCT and IL-6 differ significantly in the three groups. For ESM-1, IL-8 and CRP, the difference was statistically insignificant. The best sensitivity (78%) and negative predictive value (84%) was found for IL-6. The introduction into routine practice of indicators such as PCT and IL-6 may provide an opportunity to promptly optimize the diagnostic and therapeutic approach to LOS.https://jbcr.arphahub.com/article/34682/download/pdf/neonateslate-onset sepsisinflammatory markers |
| spellingShingle | Preslava Gatseva Alexander Blazhev Zarko Yordanov Victoria Atanasova Diagnostic Utility of Endocan and Interleukins for Late-Onset Neonatal Sepsis Journal of Biomedical & Clinical Research neonates late-onset sepsis inflammatory markers |
| title | Diagnostic Utility of Endocan and Interleukins for Late-Onset Neonatal Sepsis |
| title_full | Diagnostic Utility of Endocan and Interleukins for Late-Onset Neonatal Sepsis |
| title_fullStr | Diagnostic Utility of Endocan and Interleukins for Late-Onset Neonatal Sepsis |
| title_full_unstemmed | Diagnostic Utility of Endocan and Interleukins for Late-Onset Neonatal Sepsis |
| title_short | Diagnostic Utility of Endocan and Interleukins for Late-Onset Neonatal Sepsis |
| title_sort | diagnostic utility of endocan and interleukins for late onset neonatal sepsis |
| topic | neonates late-onset sepsis inflammatory markers |
| url | https://jbcr.arphahub.com/article/34682/download/pdf/ |
| work_keys_str_mv | AT preslavagatseva diagnosticutilityofendocanandinterleukinsforlateonsetneonatalsepsis AT alexanderblazhev diagnosticutilityofendocanandinterleukinsforlateonsetneonatalsepsis AT zarkoyordanov diagnosticutilityofendocanandinterleukinsforlateonsetneonatalsepsis AT victoriaatanasova diagnosticutilityofendocanandinterleukinsforlateonsetneonatalsepsis |