Paracetamol: Therapeutic Use and the Problem of Acute Intoxications
As a review of literature, the authors discuss the mechanisms of action and the therapeutic use of paracetamol, one of the most known and widely used drugs. In 1995, the WHO experts comparatively evaluated drugs from different groups, which have a combined analgesic and antipyretic activity. Paracet...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2007-02-01
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| Series: | Общая реаниматология |
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| Online Access: | https://www.reanimatology.com/rmt/article/view/1088 |
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| author | Ye. M. Shifman A. L. Yershov |
| author_facet | Ye. M. Shifman A. L. Yershov |
| author_sort | Ye. M. Shifman |
| collection | DOAJ |
| description | As a review of literature, the authors discuss the mechanisms of action and the therapeutic use of paracetamol, one of the most known and widely used drugs. In 1995, the WHO experts comparatively evaluated drugs from different groups, which have a combined analgesic and antipyretic activity. Paracetamol holds the lead in its efficacy/safety. An interest in the mechanism of action of the drug, as well as discussion of its safe use have again quickened due to the given ability to administer intravenous paracetamol for postoperative analgesia. Based on the review of literature, the authors draw a conclusion that paracetamol may be successfully used in practice of an intensive care unit. This drug has rather marked intrinsic analgesic and antipyretic effects and its coadministration with narcotic analgesics leads to synergism and reduces needs for opioids. When used in therapeutic doses, paracetamol is practically safe, but requires that a weighed approach be applied to its use in risk-group patients. |
| format | Article |
| id | doaj-art-f1dbd67eb96e4642b80c43917ab5e93d |
| institution | Matheson Library |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2007-02-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-f1dbd67eb96e4642b80c43917ab5e93d2025-08-04T10:40:37ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102007-02-0131576510.15360/1813-9779-2007-1-57-651088Paracetamol: Therapeutic Use and the Problem of Acute IntoxicationsYe. M. Shifman0A. L. Yershov1Republican Perinatal Center, Petrozavodsk, Republic of KareliaAll-Russian Center of Emergency and Radiation Medicine, Ministry of Emergencies of Russia, Saint PetersburgAs a review of literature, the authors discuss the mechanisms of action and the therapeutic use of paracetamol, one of the most known and widely used drugs. In 1995, the WHO experts comparatively evaluated drugs from different groups, which have a combined analgesic and antipyretic activity. Paracetamol holds the lead in its efficacy/safety. An interest in the mechanism of action of the drug, as well as discussion of its safe use have again quickened due to the given ability to administer intravenous paracetamol for postoperative analgesia. Based on the review of literature, the authors draw a conclusion that paracetamol may be successfully used in practice of an intensive care unit. This drug has rather marked intrinsic analgesic and antipyretic effects and its coadministration with narcotic analgesics leads to synergism and reduces needs for opioids. When used in therapeutic doses, paracetamol is practically safe, but requires that a weighed approach be applied to its use in risk-group patients.https://www.reanimatology.com/rmt/article/view/1088paracetamolanalgesiaantipyretic effectnarcotic analgesicsreductionopioidsrisk groups |
| spellingShingle | Ye. M. Shifman A. L. Yershov Paracetamol: Therapeutic Use and the Problem of Acute Intoxications Общая реаниматология paracetamol analgesia antipyretic effect narcotic analgesics reduction opioids risk groups |
| title | Paracetamol: Therapeutic Use and the Problem of Acute Intoxications |
| title_full | Paracetamol: Therapeutic Use and the Problem of Acute Intoxications |
| title_fullStr | Paracetamol: Therapeutic Use and the Problem of Acute Intoxications |
| title_full_unstemmed | Paracetamol: Therapeutic Use and the Problem of Acute Intoxications |
| title_short | Paracetamol: Therapeutic Use and the Problem of Acute Intoxications |
| title_sort | paracetamol therapeutic use and the problem of acute intoxications |
| topic | paracetamol analgesia antipyretic effect narcotic analgesics reduction opioids risk groups |
| url | https://www.reanimatology.com/rmt/article/view/1088 |
| work_keys_str_mv | AT yemshifman paracetamoltherapeuticuseandtheproblemofacuteintoxications AT alyershov paracetamoltherapeuticuseandtheproblemofacuteintoxications |