Echocardiographic assessment of left ventricular myocardial strain, as a non-invasive method for diagnosing pulmonary hypertension in patients with end-stage chronic kidney disease
Background. Pulmonary hypertension is a common complication of chronic kidney disease, with incidence of up to 50%. Currently, the prognostic significance of non-invasive diagnostic methods for pulmonary hypertension in patients with chronic kidney disease remains relevant.Aim. To determine the sign...
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N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department
2023-12-01
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| Series: | Трансплантология (Москва) |
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| Online Access: | https://www.jtransplantologiya.ru/jour/article/view/822 |
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| author | M. Sh. Khubutiya E. V. Shuvalova L. T. Khamidova A. A. Ivannikov A. G. Balkarov I. V. Dmitriev Kh. G. Alidzhanova |
| author_facet | M. Sh. Khubutiya E. V. Shuvalova L. T. Khamidova A. A. Ivannikov A. G. Balkarov I. V. Dmitriev Kh. G. Alidzhanova |
| author_sort | M. Sh. Khubutiya |
| collection | DOAJ |
| description | Background. Pulmonary hypertension is a common complication of chronic kidney disease, with incidence of up to 50%. Currently, the prognostic significance of non-invasive diagnostic methods for pulmonary hypertension in patients with chronic kidney disease remains relevant.Aim. To determine the significance of transthoracic echocardiography in diagnosing pulmonary hypertension in patients with end-stage chronic kidney disease.Material and methods. The study group consisted of 53 patients with chronic kidney disease stage 5D who were evaluated for kidney transplantation at the N.V. Sklifosovsky Research Institute for Emergency Medicine in 2022. A control group was represented by 24 healthy volunteers. Transthoracic echocardiography was performed on all patients according to a standard protocol, with determination of left ventricular myocardial strain indices.Results. A statistically significant correlation was found between the left ventricular global longitudinal strain and pulmonary artery systolic pressure r=0.488 (p<0.001), as well as between the left ventricular global circumferential strain and pulmonary artery systolic pressure (r=0.545, p<0.001). Regression analysis showed that an increase in pulmonary artery systolic pressure by 1 mmHg increased the odds of lethal outcome by 13% (Odds ratio: 1.13; 95% Confidence interval: [1.05;1.22], p=0.002).Conclusions. Hemodialysis patients are characterized by the development of pre-capillary pulmonary hypertension, which significantly affects their prognosis. Determination of left ventricular myocardial strain indices based on echocardiography provides additional information on the hemodynamics of the pulmonary circulation without using invasive diagnostic methods. |
| format | Article |
| id | doaj-art-f1dab8e945ee486e9aa56e07390bd9aa |
| institution | Matheson Library |
| issn | 2074-0506 2542-0909 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department |
| record_format | Article |
| series | Трансплантология (Москва) |
| spelling | doaj-art-f1dab8e945ee486e9aa56e07390bd9aa2025-08-04T10:31:19ZengN.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare DepartmentТрансплантология (Москва)2074-05062542-09092023-12-0115443944910.23873/2074-0506-2023-15-4-439-449585Echocardiographic assessment of left ventricular myocardial strain, as a non-invasive method for diagnosing pulmonary hypertension in patients with end-stage chronic kidney diseaseM. Sh. Khubutiya0E. V. Shuvalova1L. T. Khamidova2A. A. Ivannikov3A. G. Balkarov4I. V. Dmitriev5Kh. G. Alidzhanova6N.V. Sklifosovsky Research Institute for Emergency Medicine; A.I. Yevdokimov Moscow State University of Medicine and DentistryN.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency MedicineN.V. Sklifosovsky Research Institute for Emergency Medicine; N.I. Pirogov Russian National Research Medical University; Research Institute for Healthcare Organization and Medical ManagementN.V. Sklifosovsky Research Institute for Emergency Medicine; N.I. Pirogov Russian National Research Medical UniversityN.V. Sklifosovsky Research Institute for Emergency MedicineBackground. Pulmonary hypertension is a common complication of chronic kidney disease, with incidence of up to 50%. Currently, the prognostic significance of non-invasive diagnostic methods for pulmonary hypertension in patients with chronic kidney disease remains relevant.Aim. To determine the significance of transthoracic echocardiography in diagnosing pulmonary hypertension in patients with end-stage chronic kidney disease.Material and methods. The study group consisted of 53 patients with chronic kidney disease stage 5D who were evaluated for kidney transplantation at the N.V. Sklifosovsky Research Institute for Emergency Medicine in 2022. A control group was represented by 24 healthy volunteers. Transthoracic echocardiography was performed on all patients according to a standard protocol, with determination of left ventricular myocardial strain indices.Results. A statistically significant correlation was found between the left ventricular global longitudinal strain and pulmonary artery systolic pressure r=0.488 (p<0.001), as well as between the left ventricular global circumferential strain and pulmonary artery systolic pressure (r=0.545, p<0.001). Regression analysis showed that an increase in pulmonary artery systolic pressure by 1 mmHg increased the odds of lethal outcome by 13% (Odds ratio: 1.13; 95% Confidence interval: [1.05;1.22], p=0.002).Conclusions. Hemodialysis patients are characterized by the development of pre-capillary pulmonary hypertension, which significantly affects their prognosis. Determination of left ventricular myocardial strain indices based on echocardiography provides additional information on the hemodynamics of the pulmonary circulation without using invasive diagnostic methods.https://www.jtransplantologiya.ru/jour/article/view/822end-stage chronic kidney diseasepulmonary hypertensionchronic heart failureglobal longitudinal strain of the left ventricular myocardiumglobal circumferential strain of the left ventricular myocardium |
| spellingShingle | M. Sh. Khubutiya E. V. Shuvalova L. T. Khamidova A. A. Ivannikov A. G. Balkarov I. V. Dmitriev Kh. G. Alidzhanova Echocardiographic assessment of left ventricular myocardial strain, as a non-invasive method for diagnosing pulmonary hypertension in patients with end-stage chronic kidney disease Трансплантология (Москва) end-stage chronic kidney disease pulmonary hypertension chronic heart failure global longitudinal strain of the left ventricular myocardium global circumferential strain of the left ventricular myocardium |
| title | Echocardiographic assessment of left ventricular myocardial strain, as a non-invasive method for diagnosing pulmonary hypertension in patients with end-stage chronic kidney disease |
| title_full | Echocardiographic assessment of left ventricular myocardial strain, as a non-invasive method for diagnosing pulmonary hypertension in patients with end-stage chronic kidney disease |
| title_fullStr | Echocardiographic assessment of left ventricular myocardial strain, as a non-invasive method for diagnosing pulmonary hypertension in patients with end-stage chronic kidney disease |
| title_full_unstemmed | Echocardiographic assessment of left ventricular myocardial strain, as a non-invasive method for diagnosing pulmonary hypertension in patients with end-stage chronic kidney disease |
| title_short | Echocardiographic assessment of left ventricular myocardial strain, as a non-invasive method for diagnosing pulmonary hypertension in patients with end-stage chronic kidney disease |
| title_sort | echocardiographic assessment of left ventricular myocardial strain as a non invasive method for diagnosing pulmonary hypertension in patients with end stage chronic kidney disease |
| topic | end-stage chronic kidney disease pulmonary hypertension chronic heart failure global longitudinal strain of the left ventricular myocardium global circumferential strain of the left ventricular myocardium |
| url | https://www.jtransplantologiya.ru/jour/article/view/822 |
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