Virtual and experimental screening of new melatonin bioisosteres for the treatment of glaucoma

Virtual and experimental screening of new melatonin bioisosteres for the treatment of glaucoma

Background. Melatonin is an endogenous regulator of intraocular pressure (IOP), but its effectiveness as a drug for glaucoma treatment is limited.The  aim of  the  study. To develop and  to  validate a  virtual screening method to identify bioisosteric analogs of melatonin that are promising for stu...

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Bibliographic Details
Main Authors: D. A. Babkov, A. S. Taran, A. A. Shevchenko, L. V. Naumenko, O. N. Zhukovskaya, A. M. Efremov, E. N. Bezsonova, N. A. Lozinskaya, A. A. Spasov
Format: Article
Language:Russian
Published: Scientific Сentre for Family Health and Human Reproduction Problems 2024-03-01
Series:Acta Biomedica Scientifica
Subjects:
isostere
melatonin
glaucoma
intraocular pressure
virtual screening
Online Access:https://www.actabiomedica.ru/jour/article/view/4606
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