The interaction of the dietary antioxidant status indices and paraoxonase1 rs662 polymorphism on the lipid profile and severity of coronary artery stenosis in adults undergoing coronary angiography
Background and aim: The inconsistency in the results of studies related to the effect of dietary antioxidant factors on the state of health and disease prompted us to investigate the interaction of dietary antioxidant indices—namely the Dietary Antioxidant Index (DAI), the Dietary Antioxidant Qualit...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-08-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464625002774 |
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| Summary: | Background and aim: The inconsistency in the results of studies related to the effect of dietary antioxidant factors on the state of health and disease prompted us to investigate the interaction of dietary antioxidant indices—namely the Dietary Antioxidant Index (DAI), the Dietary Antioxidant Quality Score (DAQS) and the Dietary Phytochemical Index (DPI)—and the paraoxonase1(PON1) rs662 polymorphism on lipid profile markers and severity of coronary stenosis. Methods and results: This cross-sectional study was conducted on 425 patients undergoing angiography. The PON1 genotypes (QQ, QR, and RR) were detected by the polymerase chain reaction-restriction fragment length polymorphism (RFLP-PCR) technique. To compare individuals based on the presence of the dominant allele, the population is divided into two groups: those lacking the dominant allele (QQ) and those carrying at least one copy of the dominant allele (genotypes QR or RR). Dietary intake was evaluated using a Food Frequency Questionnaire (FFQ). Results: Accordingly, high adherence to the DAI decreased the odds of low HDL-C in R allele carriers compared to QQ genotype carriers by 0.64 (OR: 0.36, 95 % CI 0.15–0.86, P = 0.02). This interaction remained statistically significant after adjustment for age, gender, energy intake, physical activity, smoking, medication use, BMI, and married status (P interaction = 0.05). There was a significant interaction between the rs662 variants and the DAQS on the risk of severe coronary artery disease in the crude model (P = 0.02) but not in the adjusted model. Also, there was an interaction between adherence to DPI and variants of rs662 on odds of high triglyceride (P interaction = 0.03). Based on these interactions, when adherence to the DPI was high, R allele carriers had lower odds of high triglyceride than those with the QQ genotype (OR 0.33, 95 %CI 0.12–0.87; P = 0.02). Conclusion: R allele carriers may more benefit from consuming a diet high in antioxidants, than QQ genotype carriers concerning high triglycerides and low-HDL-C. |
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| ISSN: | 1756-4646 |