Key Connectomes and Synaptic‐Compartment‐Specific Risk Genes Drive Pathological α‐Synuclein Spreading

Key Connectomes and Synaptic‐Compartment‐Specific Risk Genes Drive Pathological α‐Synuclein Spreading

Abstract Previous studies have suggested that pathological α‐synuclein (α‐Syn) mainly transmits along the neuronal network, but several key questions remain unanswered: 1) How many and which connections in the connectome are necessary for predicting the progression of pathological α‐Syn? 2) How to i...

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Bibliographic Details
Main Authors: Yuanxi Li, Justin Torok, Shujing Zhang, Jessica Ding, Ning Wang, Courtney Lau, Shruti Kulkarni, Chaitali Anand, Julie Tran, Michael Cheng, Claire Lo, Binbin Lu, Yanzi Sun, Robert Damoiseaux, Xia Yang, Ashish Raj, Chao Peng
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Advanced Science
Subjects:
key connectomes
mathematical models
pathological α‐synuclein
risk genes
systems biology analyses
Online Access:https://doi.org/10.1002/advs.202413052
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