“Acceptable” concentrations of enrofloxacin in food lead to reduced enrofloxacin susceptibility in a mouse model of gastrointestinal Klebsiella pneumoniae

“Acceptable” concentrations of enrofloxacin in food lead to reduced enrofloxacin susceptibility in a mouse model of gastrointestinal Klebsiella pneumoniae

ABSTRACT Concentrations of antimicrobials up to 1,000-fold lower than the minimum inhibitory concentration can select for antimicrobial resistance. This generates the hypothesis that the low concentrations of antimicrobials allowed in our food could select for resistance. We assessed if the dose of...

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Bibliographic Details
Main Authors: Zina Gestels, Bianca Torfs, Said Abdellati, Irith De Baetselier, Caroline Rombouts, Veronique Dermauw, Sheeba Santhini Manoharan-Basil, Chris Kenyon
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:Microbiology Spectrum
Subjects:
minimum selection concentration
acceptable daily intake
ADI
Klebsiella pneumoniae
enrofloxacin
antimicrobial resistance
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00385-25
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