C-Phycocyanin Extract Modulates Thermogenic and Inflammatory Markers in Brown Adipose Tissue of High-Fat Diet-Fed Animals
C-phycocyanin (CPC), a bioactive compound derived from Spirulina, has been described as a molecule with antioxidant and anti-inflammatory properties. It has also been demonstrated that sustainably obtained CPC effectively inhibited body mass gain, regulated serum leptin and resistin levels, and prev...
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MDPI AG
2025-06-01
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| author | Artur Francisco Silva-Neto Julia Ferreira Rocha Gustavo Oliveira Lima Juliana Miki Oguma Vivien Cayres Giarola Suannes Pucci Yasmin Alaby Martins Ferreira Maria Isabel Alonso-Vale Claudia Maria Oller do Nascimento Mônica Marques Telles Anna Rafaela Cavalcante Braga Luciana Chagas Caperuto Lila Missae Oyama |
| author_facet | Artur Francisco Silva-Neto Julia Ferreira Rocha Gustavo Oliveira Lima Juliana Miki Oguma Vivien Cayres Giarola Suannes Pucci Yasmin Alaby Martins Ferreira Maria Isabel Alonso-Vale Claudia Maria Oller do Nascimento Mônica Marques Telles Anna Rafaela Cavalcante Braga Luciana Chagas Caperuto Lila Missae Oyama |
| author_sort | Artur Francisco Silva-Neto |
| collection | DOAJ |
| description | C-phycocyanin (CPC), a bioactive compound derived from Spirulina, has been described as a molecule with antioxidant and anti-inflammatory properties. It has also been demonstrated that sustainably obtained CPC effectively inhibited body mass gain, regulated serum leptin and resistin levels, and prevented the onset of a pro-inflammatory state in Swiss mice fed a hyperlipidic diet. These results highlighted the anti-obesogenic potential of CPC. Brown adipose tissue (BAT) has been identified as a promising target in the treatment of obesity, playing a role in energy expenditure. In this study, Swiss mice fed a high-fat diet were supplemented with 500 mg/kg body weight of CPC daily for 12 and 16 weeks. BAT was collected, and Western blot and ELISA were performed. A reduction in pro-inflammatory cytokines, as well as a decrease in leptin levels was observed in the tissue, which was also associated with a reduction in BAT relative weight to body mass. Furthermore, CPC administration was able to modulate uncoupling protein 1 (UCP1) levels, which is crucial in the thermogenesis process. Therefore, this study demonstrated that supplementation with CPC reduces inflammatory cytokines associated with detrimental effects in the BAT, emerging as a tool in combating obesity and improving BAT function. |
| format | Article |
| id | doaj-art-f0f45b1591aa4ad39d43b06dd992d6af |
| institution | Matheson Library |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-f0f45b1591aa4ad39d43b06dd992d6af2025-06-25T14:13:29ZengMDPI AGMolecules1420-30492025-06-013012253710.3390/molecules30122537C-Phycocyanin Extract Modulates Thermogenic and Inflammatory Markers in Brown Adipose Tissue of High-Fat Diet-Fed AnimalsArtur Francisco Silva-Neto0Julia Ferreira Rocha1Gustavo Oliveira Lima2Juliana Miki Oguma3Vivien Cayres Giarola Suannes Pucci4Yasmin Alaby Martins Ferreira5Maria Isabel Alonso-Vale6Claudia Maria Oller do Nascimento7Mônica Marques Telles8Anna Rafaela Cavalcante Braga9Luciana Chagas Caperuto10Lila Missae Oyama11Department of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04023-062, BrazilDepartment of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04023-062, BrazilDepartment of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04023-062, BrazilDepartment of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04023-062, BrazilDepartment of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04023-062, BrazilDepartment of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04023-062, BrazilDepartment of Biological Sciences, Institute of Environmental Chemical and Pharmaceutical Sciences, Federal University of São Paulo, Diadema 09972-270, BrazilDepartment of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04023-062, BrazilDepartment of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04023-062, BrazilDepartment of Chemical Engineering, Campus Diadema, Universidade Federal de São Paulo, Diadema 09972-270, BrazilDepartment of Biological Sciences, Institute of Environmental Chemical and Pharmaceutical Sciences, Federal University of São Paulo, Diadema 09972-270, BrazilDepartment of Physiology, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04023-062, BrazilC-phycocyanin (CPC), a bioactive compound derived from Spirulina, has been described as a molecule with antioxidant and anti-inflammatory properties. It has also been demonstrated that sustainably obtained CPC effectively inhibited body mass gain, regulated serum leptin and resistin levels, and prevented the onset of a pro-inflammatory state in Swiss mice fed a hyperlipidic diet. These results highlighted the anti-obesogenic potential of CPC. Brown adipose tissue (BAT) has been identified as a promising target in the treatment of obesity, playing a role in energy expenditure. In this study, Swiss mice fed a high-fat diet were supplemented with 500 mg/kg body weight of CPC daily for 12 and 16 weeks. BAT was collected, and Western blot and ELISA were performed. A reduction in pro-inflammatory cytokines, as well as a decrease in leptin levels was observed in the tissue, which was also associated with a reduction in BAT relative weight to body mass. Furthermore, CPC administration was able to modulate uncoupling protein 1 (UCP1) levels, which is crucial in the thermogenesis process. Therefore, this study demonstrated that supplementation with CPC reduces inflammatory cytokines associated with detrimental effects in the BAT, emerging as a tool in combating obesity and improving BAT function.https://www.mdpi.com/1420-3049/30/12/2537C-phycocyaninhigh-fat dietbrown adipose tissuemetabolisminflammatory markersUCP-1 |
| spellingShingle | Artur Francisco Silva-Neto Julia Ferreira Rocha Gustavo Oliveira Lima Juliana Miki Oguma Vivien Cayres Giarola Suannes Pucci Yasmin Alaby Martins Ferreira Maria Isabel Alonso-Vale Claudia Maria Oller do Nascimento Mônica Marques Telles Anna Rafaela Cavalcante Braga Luciana Chagas Caperuto Lila Missae Oyama C-Phycocyanin Extract Modulates Thermogenic and Inflammatory Markers in Brown Adipose Tissue of High-Fat Diet-Fed Animals Molecules C-phycocyanin high-fat diet brown adipose tissue metabolism inflammatory markers UCP-1 |
| title | C-Phycocyanin Extract Modulates Thermogenic and Inflammatory Markers in Brown Adipose Tissue of High-Fat Diet-Fed Animals |
| title_full | C-Phycocyanin Extract Modulates Thermogenic and Inflammatory Markers in Brown Adipose Tissue of High-Fat Diet-Fed Animals |
| title_fullStr | C-Phycocyanin Extract Modulates Thermogenic and Inflammatory Markers in Brown Adipose Tissue of High-Fat Diet-Fed Animals |
| title_full_unstemmed | C-Phycocyanin Extract Modulates Thermogenic and Inflammatory Markers in Brown Adipose Tissue of High-Fat Diet-Fed Animals |
| title_short | C-Phycocyanin Extract Modulates Thermogenic and Inflammatory Markers in Brown Adipose Tissue of High-Fat Diet-Fed Animals |
| title_sort | c phycocyanin extract modulates thermogenic and inflammatory markers in brown adipose tissue of high fat diet fed animals |
| topic | C-phycocyanin high-fat diet brown adipose tissue metabolism inflammatory markers UCP-1 |
| url | https://www.mdpi.com/1420-3049/30/12/2537 |
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