Comparison of Caffeine and Aminophylline in Treating Apnea of Prematurity with Historical Data: A Single Center, Observational Study in Taiwan
Background: For treatment of apnea of prematurity (AOP), aminophylline is the first line medication in Taiwan. There are limited trials in Taiwan regarding the therapeutic benefits and adverse effects of caffeine for the treatment of AOP.Methods: This observational study conducted between January 20...
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| Format: | Article |
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Mashhad University of Medical Sciences
2025-01-01
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| Series: | Iranian Journal of Neonatology |
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| Online Access: | https://ijn.mums.ac.ir/article_25047_7e1c5b6d4526583ccf737c6a60527ae9.pdf |
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| author | Fong-Cheng Ho Tsai-Hui Duh Hao-Wei Chung Shu-Ting Yang Hsiu-Lin Chen |
| author_facet | Fong-Cheng Ho Tsai-Hui Duh Hao-Wei Chung Shu-Ting Yang Hsiu-Lin Chen |
| author_sort | Fong-Cheng Ho |
| collection | DOAJ |
| description | Background: For treatment of apnea of prematurity (AOP), aminophylline is the first line medication in Taiwan. There are limited trials in Taiwan regarding the therapeutic benefits and adverse effects of caffeine for the treatment of AOP.Methods: This observational study conducted between January 2018 and December 2018 investigated the clinical effectiveness and safety of caffeine for AOP in the neonatal intensive care unit (NICU) at a hospital in Taiwan. Very preterm neonates with very low birth weight and apnea were treated with a loading dose of caffeine citrate at 20 mg/kg, followed by a 5–10 mg/kg maintenance dose every 24 h. Preterm infants admitted to the NICU between January 2017 and December 2018 and treated with aminophylline/theophylline were included for comparison.Results: Seventeen infants receiving caffeine therapy and 43 receiving aminophylline/theophylline therapy were enrolled in this study. Although fewer apneic spells were observed from the second week of commencing caffeine treatment (P=0.028), the mean duration of apnea and episodes of apneic spells during the first four weeks of treatment were similar between the two groups. There were no significant differences in short-term side effects, duration of intubation, noninvasive respiratory support, hospitalization, and medical expenses between the two groups.Conclusion: Caffeine treatment can reduce the frequency of apnea after one week of administration; however, both caffeine and aminophylline/theophylline showed similar effects in treating AOP. |
| format | Article |
| id | doaj-art-f097718f87f448a6b3b6d1ba4ef8dcfe |
| institution | Matheson Library |
| issn | 2251-7510 2322-2158 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Neonatology |
| spelling | doaj-art-f097718f87f448a6b3b6d1ba4ef8dcfe2025-07-30T05:07:41ZengMashhad University of Medical SciencesIranian Journal of Neonatology2251-75102322-21582025-01-01161404710.22038/ijn.2024.75703.245825047Comparison of Caffeine and Aminophylline in Treating Apnea of Prematurity with Historical Data: A Single Center, Observational Study in TaiwanFong-Cheng Ho0Tsai-Hui Duh1Hao-Wei Chung2Shu-Ting Yang3Hsiu-Lin Chen4Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80756, TaiwanDepartment of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 80708, TaiwanDepartment of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80756, TaiwanDepartment of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80756, TaiwanDepartment of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80756, TaiwanBackground: For treatment of apnea of prematurity (AOP), aminophylline is the first line medication in Taiwan. There are limited trials in Taiwan regarding the therapeutic benefits and adverse effects of caffeine for the treatment of AOP.Methods: This observational study conducted between January 2018 and December 2018 investigated the clinical effectiveness and safety of caffeine for AOP in the neonatal intensive care unit (NICU) at a hospital in Taiwan. Very preterm neonates with very low birth weight and apnea were treated with a loading dose of caffeine citrate at 20 mg/kg, followed by a 5–10 mg/kg maintenance dose every 24 h. Preterm infants admitted to the NICU between January 2017 and December 2018 and treated with aminophylline/theophylline were included for comparison.Results: Seventeen infants receiving caffeine therapy and 43 receiving aminophylline/theophylline therapy were enrolled in this study. Although fewer apneic spells were observed from the second week of commencing caffeine treatment (P=0.028), the mean duration of apnea and episodes of apneic spells during the first four weeks of treatment were similar between the two groups. There were no significant differences in short-term side effects, duration of intubation, noninvasive respiratory support, hospitalization, and medical expenses between the two groups.Conclusion: Caffeine treatment can reduce the frequency of apnea after one week of administration; however, both caffeine and aminophylline/theophylline showed similar effects in treating AOP.https://ijn.mums.ac.ir/article_25047_7e1c5b6d4526583ccf737c6a60527ae9.pdfapnea of prematuritycaffeinemethylxanthinepreterm |
| spellingShingle | Fong-Cheng Ho Tsai-Hui Duh Hao-Wei Chung Shu-Ting Yang Hsiu-Lin Chen Comparison of Caffeine and Aminophylline in Treating Apnea of Prematurity with Historical Data: A Single Center, Observational Study in Taiwan Iranian Journal of Neonatology apnea of prematurity caffeine methylxanthine preterm |
| title | Comparison of Caffeine and Aminophylline in Treating Apnea of Prematurity with Historical Data: A Single Center, Observational Study in Taiwan |
| title_full | Comparison of Caffeine and Aminophylline in Treating Apnea of Prematurity with Historical Data: A Single Center, Observational Study in Taiwan |
| title_fullStr | Comparison of Caffeine and Aminophylline in Treating Apnea of Prematurity with Historical Data: A Single Center, Observational Study in Taiwan |
| title_full_unstemmed | Comparison of Caffeine and Aminophylline in Treating Apnea of Prematurity with Historical Data: A Single Center, Observational Study in Taiwan |
| title_short | Comparison of Caffeine and Aminophylline in Treating Apnea of Prematurity with Historical Data: A Single Center, Observational Study in Taiwan |
| title_sort | comparison of caffeine and aminophylline in treating apnea of prematurity with historical data a single center observational study in taiwan |
| topic | apnea of prematurity caffeine methylxanthine preterm |
| url | https://ijn.mums.ac.ir/article_25047_7e1c5b6d4526583ccf737c6a60527ae9.pdf |
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