Formulation and Optimization of Aceclofenac Loaded Nanosuspension
Background: The aceclofenac sodium is used as non-steroidal anti inflammatory drug (NSAID), administered through the oral route, causing numerous side effects like nausea, vomiting, dyspepsia, gastrointestinal bleeding and peptic ulcer. NSAIDs, promote the secretions of hydrochloric acid which caus...
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Superior University Lahore, Pakistan
2021-12-01
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| Series: | International Journal of Pharmacy & Integrated Health Sciences |
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| Online Access: | https://ijpihs.pk/index.php/IJPIHS/article/view/15 |
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Background: The aceclofenac sodium is used as non-steroidal anti inflammatory drug (NSAID), administered through the oral route, causing numerous side effects like nausea, vomiting, dyspepsia, gastrointestinal bleeding and peptic ulcer. NSAIDs, promote the secretions of hydrochloric acid which cause severe damage to the walls of gastro intestinal tracts well as to the drug.
Objectives: Aceclofenac was added in combination with different polymers to form a uniform nano suspension.
Methodology: Three sets of formulations were prepared by using silverson mixer. The organoleptic evaluation, particle size determination, assay, in vitro drug release study and drug excipient compatibility studies were performed. The results were obtained on the basis of drug and excipients compatibility studies, scanning electron microscopy, In vitro drug release study and assay studies.
Results: In this study, the nanosuspension of aceclofenac sodium is produced, which spread on the wider surface area of GIT. Due to this reason, the decrease in accumulated concentration, the secretion of hydrochloric acid is not promoted, the chance of damage to GIT is drastically reduced, and the drug also escaped from the damage and the absorption of drug is also increased.
Conclusion: The F1 formulation showed best results as compared to other two formulations. These results were obtained due to the effect of polymers used in combination with drug and surfactant.
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| format | Article |
| id | doaj-art-f070f42e1e3c47acb9fbd4530c77df13 |
| institution | Matheson Library |
| issn | 2958-1656 2789-2840 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | Superior University Lahore, Pakistan |
| record_format | Article |
| series | International Journal of Pharmacy & Integrated Health Sciences |
| spelling | doaj-art-f070f42e1e3c47acb9fbd4530c77df132025-07-04T06:48:22ZengSuperior University Lahore, PakistanInternational Journal of Pharmacy & Integrated Health Sciences2958-16562789-28402021-12-012110.56536/ijpihs.v2i1.15Formulation and Optimization of Aceclofenac Loaded Nanosuspension Background: The aceclofenac sodium is used as non-steroidal anti inflammatory drug (NSAID), administered through the oral route, causing numerous side effects like nausea, vomiting, dyspepsia, gastrointestinal bleeding and peptic ulcer. NSAIDs, promote the secretions of hydrochloric acid which cause severe damage to the walls of gastro intestinal tracts well as to the drug. Objectives: Aceclofenac was added in combination with different polymers to form a uniform nano suspension. Methodology: Three sets of formulations were prepared by using silverson mixer. The organoleptic evaluation, particle size determination, assay, in vitro drug release study and drug excipient compatibility studies were performed. The results were obtained on the basis of drug and excipients compatibility studies, scanning electron microscopy, In vitro drug release study and assay studies. Results: In this study, the nanosuspension of aceclofenac sodium is produced, which spread on the wider surface area of GIT. Due to this reason, the decrease in accumulated concentration, the secretion of hydrochloric acid is not promoted, the chance of damage to GIT is drastically reduced, and the drug also escaped from the damage and the absorption of drug is also increased. Conclusion: The F1 formulation showed best results as compared to other two formulations. These results were obtained due to the effect of polymers used in combination with drug and surfactant. https://ijpihs.pk/index.php/IJPIHS/article/view/15AceclofenacNanosuspensiongastrointestinal side effectSilverson mixerScanning electron microscopy |
| spellingShingle | Formulation and Optimization of Aceclofenac Loaded Nanosuspension International Journal of Pharmacy & Integrated Health Sciences Aceclofenac Nanosuspension gastrointestinal side effect Silverson mixer Scanning electron microscopy |
| title | Formulation and Optimization of Aceclofenac Loaded Nanosuspension |
| title_full | Formulation and Optimization of Aceclofenac Loaded Nanosuspension |
| title_fullStr | Formulation and Optimization of Aceclofenac Loaded Nanosuspension |
| title_full_unstemmed | Formulation and Optimization of Aceclofenac Loaded Nanosuspension |
| title_short | Formulation and Optimization of Aceclofenac Loaded Nanosuspension |
| title_sort | formulation and optimization of aceclofenac loaded nanosuspension |
| topic | Aceclofenac Nanosuspension gastrointestinal side effect Silverson mixer Scanning electron microscopy |
| url | https://ijpihs.pk/index.php/IJPIHS/article/view/15 |