Clinical practice guidelines for acute kidney injury: a systematic review of the methodological quality
ObjectiveHospitalized patients, particularly those in the ICU, face a significant risk of acute kidney injury (AKI). Clinical practice guidelines (CPGs) that outline diagnostic and therapeutic strategies for AKI can be valuable tools for healthcare professionals, but their effectiveness hinges on th...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1567359/full |
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| author | Ruizhe Li Lanxia Wu Xinhui Wu Qingyang Fu Mingyu Xu Xu Zhai Junfei Chen |
| author_facet | Ruizhe Li Lanxia Wu Xinhui Wu Qingyang Fu Mingyu Xu Xu Zhai Junfei Chen |
| author_sort | Ruizhe Li |
| collection | DOAJ |
| description | ObjectiveHospitalized patients, particularly those in the ICU, face a significant risk of acute kidney injury (AKI). Clinical practice guidelines (CPGs) that outline diagnostic and therapeutic strategies for AKI can be valuable tools for healthcare professionals, but their effectiveness hinges on their quality. The research aims to conduct a systematic review focusing on the methodological and reporting quality of CPGs addressing acute kidney injury.DesignA systematic review of CPGs for the management of acute kidney injury in adult patients.Data resourcesPubMed and other related databases were systematically searched from January 2012 to January 2023 to collect clinical guidelines and expert consensus on acute kidney injury. After summarizing the basic information, the methodological and reporting quality of the included guidelines or expert consensus was evaluated using the AGREE II and RIGHT tools.ResultsA total of 8 CPGs from 6 countries and regions were included in this study, and the period was 2012–2023. In terms of methodological quality, 1 guideline was a level strongly recommended, and 6 were level B, generally recommended guidelines. While the evaluated guidelines demonstrated moderate overall reporting completeness, critical deficiencies persist in contextual transparency and quality assurance protocols, necessitating prioritized remediation in future iterations.ConclusionOur appraisal identifies the 2012 KDIGO guideline as the highest-quality AKI guidance framework currently available, which has driven global standardization of diagnostic criteria and management protocols. Our analysis reveals critical gaps in the practical applicability and transparency of current clinical practice guidelines, particularly regarding implementation strategies tailored to different populations, such as aging populations. Future iterations must prioritize demographic inclusivity, with explicit recommendations addressing the diagnostic challenges and management complexities of AKI among different populations. |
| format | Article |
| id | doaj-art-f00d4a8e7c9242f7adb60d910b357c95 |
| institution | Matheson Library |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-f00d4a8e7c9242f7adb60d910b357c952025-07-24T05:33:19ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-07-011210.3389/fmed.2025.15673591567359Clinical practice guidelines for acute kidney injury: a systematic review of the methodological qualityRuizhe Li0Lanxia Wu1Xinhui Wu2Qingyang Fu3Mingyu Xu4Xu Zhai5Junfei Chen6Department of Cardiology, Peking University Third Hospital, Beijing University, Beijing, ChinaSchool of Psychology, Shandong Second Medical University, Weifang, ChinaDepartment of Nephrology, Shandong Electric Power Central Hospital, Jinan, ChinaDepartment of Orthopedics, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Orthopedics, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Orthopedics, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Pediatric Surgery, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, ChinaObjectiveHospitalized patients, particularly those in the ICU, face a significant risk of acute kidney injury (AKI). Clinical practice guidelines (CPGs) that outline diagnostic and therapeutic strategies for AKI can be valuable tools for healthcare professionals, but their effectiveness hinges on their quality. The research aims to conduct a systematic review focusing on the methodological and reporting quality of CPGs addressing acute kidney injury.DesignA systematic review of CPGs for the management of acute kidney injury in adult patients.Data resourcesPubMed and other related databases were systematically searched from January 2012 to January 2023 to collect clinical guidelines and expert consensus on acute kidney injury. After summarizing the basic information, the methodological and reporting quality of the included guidelines or expert consensus was evaluated using the AGREE II and RIGHT tools.ResultsA total of 8 CPGs from 6 countries and regions were included in this study, and the period was 2012–2023. In terms of methodological quality, 1 guideline was a level strongly recommended, and 6 were level B, generally recommended guidelines. While the evaluated guidelines demonstrated moderate overall reporting completeness, critical deficiencies persist in contextual transparency and quality assurance protocols, necessitating prioritized remediation in future iterations.ConclusionOur appraisal identifies the 2012 KDIGO guideline as the highest-quality AKI guidance framework currently available, which has driven global standardization of diagnostic criteria and management protocols. Our analysis reveals critical gaps in the practical applicability and transparency of current clinical practice guidelines, particularly regarding implementation strategies tailored to different populations, such as aging populations. Future iterations must prioritize demographic inclusivity, with explicit recommendations addressing the diagnostic challenges and management complexities of AKI among different populations.https://www.frontiersin.org/articles/10.3389/fmed.2025.1567359/fullsystematic reviewclinical practice guidelinesevidence-basedacute renal failureacute kidney injury |
| spellingShingle | Ruizhe Li Lanxia Wu Xinhui Wu Qingyang Fu Mingyu Xu Xu Zhai Junfei Chen Clinical practice guidelines for acute kidney injury: a systematic review of the methodological quality Frontiers in Medicine systematic review clinical practice guidelines evidence-based acute renal failure acute kidney injury |
| title | Clinical practice guidelines for acute kidney injury: a systematic review of the methodological quality |
| title_full | Clinical practice guidelines for acute kidney injury: a systematic review of the methodological quality |
| title_fullStr | Clinical practice guidelines for acute kidney injury: a systematic review of the methodological quality |
| title_full_unstemmed | Clinical practice guidelines for acute kidney injury: a systematic review of the methodological quality |
| title_short | Clinical practice guidelines for acute kidney injury: a systematic review of the methodological quality |
| title_sort | clinical practice guidelines for acute kidney injury a systematic review of the methodological quality |
| topic | systematic review clinical practice guidelines evidence-based acute renal failure acute kidney injury |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1567359/full |
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