Amplification of select autonomous HERV loci and surrounding host gene transcription in monocytes from patients with post-acute sequelae of COVID-19

Amplification of select autonomous HERV loci and surrounding host gene transcription in monocytes from patients with post-acute sequelae of COVID-19

BackgroundThe human genome contains approximately 3,200 near full-length autonomous human endogenous retroviral (HERV) genomes distributed across the 23 chromosomes. These autonomous HERV proviral genomes include long terminal repeats (LTRs) capable of promoting RNA transcription. In quiescent cells...

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Bibliographic Details
Main Authors: Hyunmin Koo, Casey D. Morrow
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
post-acute COVID sequelae
monocytes
epigenetic remodeling
ScRNA-seq
human endogenous retrovirus (HERV)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1621657/full
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