The role of cathepsin S in the pathophysiology of bronchial asthma
To date, the study of the role of proteases in the pathogenesis of various diseases remains relevant. The variety of cathepsin functions is associated with the peculiarities of their localization, expression, and regulation, due to which cathepsins are involved in development of many pathologies. Dy...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2022-10-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/4921 |
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| author | A. Yu. Kraposhina E. А. Sobko I. V. Demko O. V. Kazmerchuk A. B. Kacer Yu. I. Abramov |
| author_facet | A. Yu. Kraposhina E. А. Sobko I. V. Demko O. V. Kazmerchuk A. B. Kacer Yu. I. Abramov |
| author_sort | A. Yu. Kraposhina |
| collection | DOAJ |
| description | To date, the study of the role of proteases in the pathogenesis of various diseases remains relevant. The variety of cathepsin functions is associated with the peculiarities of their localization, expression, and regulation, due to which cathepsins are involved in development of many pathologies. Dysregulation of proteases, their inhibitors, and substrates can lead to the development of multiple organ dysfunction.The review presents data on the characteristics of the entire family of cathepsins and cathepsin S, in particular. The pathophysiological role of cathepsin S in the formation of bronchopulmonary pathologies, as well as in bronchial asthma is described, and intraand extracellular implementation mechanisms are considered. The authors believe it is this enzyme that could be targeted in targeted asthma therapy to prevent airway wall remodeling at the earliest stages of the disease. The literature search was carried out in the search engines Medline, eLibrary, Scopus, the Cochrane Library, and RSCI. |
| format | Article |
| id | doaj-art-eecfa9ccd9ec4eb6bc3f86da292af2ba |
| institution | Matheson Library |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2022-10-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-eecfa9ccd9ec4eb6bc3f86da292af2ba2025-08-04T16:45:44ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842022-10-0121319820410.20538/1682-0363-2022-3-198-2042931The role of cathepsin S in the pathophysiology of bronchial asthmaA. Yu. Kraposhina0E. А. Sobko1I. V. Demko2O. V. Kazmerchuk3A. B. Kacer4Yu. I. Abramov5V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Regional Clinical HospitalV.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Regional Clinical HospitalV.F. Voino-Yasenetsky Krasnoyarsk State Medical University; Krasnoyarsk Regional Clinical HospitalV.F. Voino-Yasenetsky Krasnoyarsk State Medical UniversityV.F. Voino-Yasenetsky Krasnoyarsk State Medical UniversityV.F. Voino-Yasenetsky Krasnoyarsk State Medical UniversityTo date, the study of the role of proteases in the pathogenesis of various diseases remains relevant. The variety of cathepsin functions is associated with the peculiarities of their localization, expression, and regulation, due to which cathepsins are involved in development of many pathologies. Dysregulation of proteases, their inhibitors, and substrates can lead to the development of multiple organ dysfunction.The review presents data on the characteristics of the entire family of cathepsins and cathepsin S, in particular. The pathophysiological role of cathepsin S in the formation of bronchopulmonary pathologies, as well as in bronchial asthma is described, and intraand extracellular implementation mechanisms are considered. The authors believe it is this enzyme that could be targeted in targeted asthma therapy to prevent airway wall remodeling at the earliest stages of the disease. The literature search was carried out in the search engines Medline, eLibrary, Scopus, the Cochrane Library, and RSCI.https://bulletin.ssmu.ru/jour/article/view/4921cathepsin sbronchial asthmapathophysiologyproteasesairway remodeling |
| spellingShingle | A. Yu. Kraposhina E. А. Sobko I. V. Demko O. V. Kazmerchuk A. B. Kacer Yu. I. Abramov The role of cathepsin S in the pathophysiology of bronchial asthma Бюллетень сибирской медицины cathepsin s bronchial asthma pathophysiology proteases airway remodeling |
| title | The role of cathepsin S in the pathophysiology of bronchial asthma |
| title_full | The role of cathepsin S in the pathophysiology of bronchial asthma |
| title_fullStr | The role of cathepsin S in the pathophysiology of bronchial asthma |
| title_full_unstemmed | The role of cathepsin S in the pathophysiology of bronchial asthma |
| title_short | The role of cathepsin S in the pathophysiology of bronchial asthma |
| title_sort | role of cathepsin s in the pathophysiology of bronchial asthma |
| topic | cathepsin s bronchial asthma pathophysiology proteases airway remodeling |
| url | https://bulletin.ssmu.ru/jour/article/view/4921 |
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