Comparison of CISNE and MASCC Score in Predicting Complications on Post Chemotherapy Febrile Neutropenia
Background: Febrile neutropenia (FN) is an oncologic emergency which commonly occurrs in patients who undergo chemotherapy, with a mortality rate of 12.5%. Risk stratification in FN plays an important role in increasing the accuracy of therapy. This study aims to compare the performance between CIS...
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Interna Publishing
2024-10-01
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| Series: | Acta Medica Indonesiana |
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| Online Access: | http://www.actamedindones.org/index.php/ijim/article/view/2772 |
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| author | Sharifah Shakinah Erni Juwita Nelwan Anna Mira Lubis Robert Sinto Khie Chen Lie |
| author_facet | Sharifah Shakinah Erni Juwita Nelwan Anna Mira Lubis Robert Sinto Khie Chen Lie |
| author_sort | Sharifah Shakinah |
| collection | DOAJ |
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Background: Febrile neutropenia (FN) is an oncologic emergency which commonly occurrs in patients who undergo chemotherapy, with a mortality rate of 12.5%. Risk stratification in FN plays an important role in increasing the accuracy of therapy. This study aims to compare the performance between CISNE score and MASCC score in predicting complications on post-chemotherapy FN in solid and hematologic malignancy. Methods: This is a retrospective cohort study on FN patients undergoing inpatient treatment at Cipto Mangunkusumo Hospital between July 2015 and December 2019. Basic demographic and clinical data were collected from medical records. Subjects were grouped based on the CISNE and MASCC score, and complications during hospitalization were recorded. Predictive performance of each score was analyzed and compared using area of under curve. Results: CISNE score showed a better performance both in solid malignancy with AUC of CISNE score (0.80 CI 95% 0.73-0.88, p = 0.00) compared to AUC of MASCC score (0.68; 95% CI 0.59 – 0,78, p = 0.00) and in hematologic malignancy with AUC of CISNE score (0.85; 95% CI 0.77 - 0.93, p = 0.00) and AUC MASCC score (0.65 ; 95% CI 0.54 - 0.76, p = 0.007). Conclusion: CISNE score showed a better performance compared to MASCC score in predicting in-hospital complication in both solid and hematologic malignancy with cut-off point of 2.
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| format | Article |
| id | doaj-art-eeca844dd4244a54aa3c423c6e5bcc4c |
| institution | Matheson Library |
| issn | 0125-9326 2338-2732 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Interna Publishing |
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| series | Acta Medica Indonesiana |
| spelling | doaj-art-eeca844dd4244a54aa3c423c6e5bcc4c2025-07-14T07:00:10ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322024-10-01563Comparison of CISNE and MASCC Score in Predicting Complications on Post Chemotherapy Febrile NeutropeniaSharifah Shakinah0Erni Juwita Nelwan1Anna Mira Lubis2Robert Sinto3Khie Chen Lie4Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Background: Febrile neutropenia (FN) is an oncologic emergency which commonly occurrs in patients who undergo chemotherapy, with a mortality rate of 12.5%. Risk stratification in FN plays an important role in increasing the accuracy of therapy. This study aims to compare the performance between CISNE score and MASCC score in predicting complications on post-chemotherapy FN in solid and hematologic malignancy. Methods: This is a retrospective cohort study on FN patients undergoing inpatient treatment at Cipto Mangunkusumo Hospital between July 2015 and December 2019. Basic demographic and clinical data were collected from medical records. Subjects were grouped based on the CISNE and MASCC score, and complications during hospitalization were recorded. Predictive performance of each score was analyzed and compared using area of under curve. Results: CISNE score showed a better performance both in solid malignancy with AUC of CISNE score (0.80 CI 95% 0.73-0.88, p = 0.00) compared to AUC of MASCC score (0.68; 95% CI 0.59 – 0,78, p = 0.00) and in hematologic malignancy with AUC of CISNE score (0.85; 95% CI 0.77 - 0.93, p = 0.00) and AUC MASCC score (0.65 ; 95% CI 0.54 - 0.76, p = 0.007). Conclusion: CISNE score showed a better performance compared to MASCC score in predicting in-hospital complication in both solid and hematologic malignancy with cut-off point of 2. http://www.actamedindones.org/index.php/ijim/article/view/2772infectious diseasemedical oncology |
| spellingShingle | Sharifah Shakinah Erni Juwita Nelwan Anna Mira Lubis Robert Sinto Khie Chen Lie Comparison of CISNE and MASCC Score in Predicting Complications on Post Chemotherapy Febrile Neutropenia Acta Medica Indonesiana infectious disease medical oncology |
| title | Comparison of CISNE and MASCC Score in Predicting Complications on Post Chemotherapy Febrile Neutropenia |
| title_full | Comparison of CISNE and MASCC Score in Predicting Complications on Post Chemotherapy Febrile Neutropenia |
| title_fullStr | Comparison of CISNE and MASCC Score in Predicting Complications on Post Chemotherapy Febrile Neutropenia |
| title_full_unstemmed | Comparison of CISNE and MASCC Score in Predicting Complications on Post Chemotherapy Febrile Neutropenia |
| title_short | Comparison of CISNE and MASCC Score in Predicting Complications on Post Chemotherapy Febrile Neutropenia |
| title_sort | comparison of cisne and mascc score in predicting complications on post chemotherapy febrile neutropenia |
| topic | infectious disease medical oncology |
| url | http://www.actamedindones.org/index.php/ijim/article/view/2772 |
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